Non-symmetric substituted ethylenediamines
Abstract
An optimal method for the synthesis of vicinal diamine salts - asymmetric alkyl derivatives of ethylenediamine, based on the conversion of carbonyl compounds by the reaction of Strecker into geminal aminonitriles and their subsequent reduction to diamines is developed. The originality of this technique lies in the fact that to minimize the side processes, amino groups are protected by BOC. The resulting diamides are stable during storage, but, if necessary, easily converted to dihydrochlorides of the corresponding diamines. Yields at all stages are high.
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References
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