Основні етапи розвитку та сучасний стан фотодинамічної терапії в Росії
Анотація
В статті представлені основні етапи 25-річного розвитку фотодинамічної терапії (ФДТ) в Росії. Відзначено, що ініціатором розробки методу ФДТ був директор ГНЦ лазерної медицини, член- кореспондент РАМН, професор О.К. Скобєлкін. Він об’єднав зусилля низки інститутів хімічного та фізичного профілю для створення вітчизняних фотосенсибілізаторів (ФС) та розробки лазерних апаратів для ФДТ. У 1990 році в Московському інституті тонкої хімічної технології ім. М.В. Ломоносова під керівництвом професора А.Ф. Міронова був розроблений перший вітчизняний фотосенсибілізатор із групи гематопорфірину — Фотогем. У ГНЦ лазерної медицини були проведені прециклічні випробування Фотогема, підготовлена матеріально-технічна база для проведення клінічної ФДТ, отримано дозволи Фармакологічного комітету на клінічні випробування і з лютого 1992 року ми почали застосовувати ФДТ у пацієнтів з рецидивними та метастатичними пухлинами, абсолютно безперспективними для традиційних методів лікування.
В наступні 6 років створено цілий ряд фотосенсибілізаторів другого покоління (фотосенс, аласценс, фотодитазин, радахлорін та ін.) та розроблена вітчизняна лазерна техніка для ФДТ та флюоресцентної діагностики. Клінічне застосування ФДТ придбало широкомасштабний характер. В даний час ФДТ застосовується при пухлинах зовнішніх та віцеральних локалізацій ракових, ранніх і поширених стадій процесу (паліативна ендоскопічна ФДТ), як компонент комбінованого та комплексного лікування раку різноманітних локалізацій. ФДТ в Росії знайшла широке застосування в цілій низці непухлинниих захворювань: у офтальмології, в гнійній хірургії, в оториноларингології, гінекології, дерматології та ін. ФДТ застосовується не тільки в інститутах і наукових центрах, але і в практичних лікувальних установах. В інститутах викладається предмет ФДТ на курсах підвищення кваліфікації лікарів. Російські вчені беруть активну участь у міжнародному співробітництві та виступають з науковими доповідями на конгресах Всесвітньої фотодинамічної асоціації та конференціях з лазерної медицини як в Росії, так і за кордоном.
Завантаження
Посилання
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