Основні етапи розвитку та сучасний стан фотодинамічної терапії в Росії

  • E. Ph. Stranadko ФДБЗ «Державний науковий центр лазерної медицини Федерального медико-біологічного агентства Росії », м. Москва, Росія https://orcid.org/0000-0002-1589-7661
  • T. I. Malova ТОВ «ВЕТА-ГРАНД», м. Москва, Росія https://orcid.org/0000-0003-0689-3754
Ключові слова: фотодинамична терапія, етапи розвитку, сучасний стан

Анотація

В статті представлені основні етапи 25-річного розвитку фотодинамічної терапії (ФДТ) в Росії. Відзначено, що ініціатором розробки методу ФДТ був директор ГНЦ лазерної медицини, член- кореспондент РАМН, професор О.К. Скобєлкін. Він об’єднав зусилля низки інститутів хімічного та фізичного профілю для створення вітчизняних фотосенсибілізаторів (ФС) та розробки лазерних апаратів для ФДТ. У 1990 році в Московському інституті тонкої хімічної технології ім. М.В. Ломоносова під керівництвом професора А.Ф. Міронова був розроблений перший вітчизняний фотосенсибілізатор із групи гематопорфірину — Фотогем. У ГНЦ лазерної медицини були проведені прециклічні випробування Фотогема, підготовлена матеріально-технічна база для проведення клінічної ФДТ, отримано дозволи Фармакологічного комітету на клінічні випробування і з лютого 1992 року ми почали застосовувати ФДТ у пацієнтів з рецидивними та метастатичними пухлинами, абсолютно безперспективними для традиційних методів лікування.

В наступні 6 років створено цілий ряд фотосенсибілізаторів другого покоління (фотосенс, аласценс, фотодитазин, радахлорін та ін.) та розроблена вітчизняна лазерна техніка для ФДТ та флюоресцентної діагностики. Клінічне застосування ФДТ придбало широкомасштабний характер. В даний час ФДТ застосовується при пухлинах зовнішніх та віцеральних локалізацій ракових, ранніх і поширених стадій процесу (паліативна ендоскопічна ФДТ), як компонент комбінованого та комплексного лікування раку різноманітних локалізацій. ФДТ в Росії знайшла широке застосування в цілій низці непухлинниих захворювань: у офтальмології, в гнійній хірургії, в оториноларингології, гінекології, дерматології та ін. ФДТ застосовується не тільки в інститутах і наукових центрах, але і в практичних лікувальних установах. В інститутах викладається предмет ФДТ на курсах підвищення кваліфікації лікарів. Російські вчені беруть активну участь у міжнародному співробітництві та виступають з науковими доповідями на конгресах Всесвітньої фотодинамічної асоціації та конференціях з лазерної медицини як в Росії, так і за кордоном.

Завантаження

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Посилання

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Опубліковано
2018-11-26
Як цитувати
Stranadko, E. P., & Malova, T. I. (2018). Основні етапи розвитку та сучасний стан фотодинамічної терапії в Росії. Фотобіологія та фотомедицина, 15(1(24), 21-27. https://doi.org/10.26565/2076-0612-2018-24-03
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