THE ROLE OF IRON DEFICIENCY ANEMIA IN PATIENTS WITH СHRONIC HEART FAILURE IN THE EXAMPLE OF A CLINICAL CASE
Anemia is common comorbidity in patients with heart failure. In Europe one in two patients with chronic heart failure has iron deficiency. Iron deficiency anemia is associated with a worse prognosis in the heart failure patient population and is an independent risk-factor for mortality, poor exercise capacity and low quality of life.
The goal of this clinical case was to bring awareness to the prevalence of anemia and CHF, and influence of iron deficiency anemia in the progression of CHF while also focusing on diagnostic testing and treatment strategies. The origins of anemia in heart failure are multifactorial. Its pathways are complex and not well understood. There is no single treatment that will suit all patients, because of treatment must be based on an understanding of the causes of anemia in each patient. According to last recommendation, the 2016 European Society of Cardiology guidelines, IV iron therapy is recommended for patients with Heart Failure with reduced Ejection Fraction and absolute or functional ID in order to alleviate HF symptoms and improve exercise capacity and quality of life. The role of anemia in developing of HF should be researched and recognized more to understand the target levels of ferritin and iron in patients with or without anemia and CHF to reduce mortality and improve quality of life
Thomas D. S. Management of anemia in chronic heart failure / D. S. Thomas, A. S. Marc // Current opinion in Cardiology. – 2010. –No 25. – p. 154.
The anemia of heart failure / S. S. Donald, P. Alberto, L. Adrian, L. Doron // Acta Haematologica. – 2009. – No. 20. – p. 119.
Hempel E. The Evidence-Based Evaluation of Iron Deficiency Anemia / E. Hempel, E. Bollard // Med Clin North Am. – 2016. –No 5. – p. 75.
Living well with chronic heart failure [Electronic resource] // Heart Foundation. – 2014. – Access mode: http://www.medscape.com/cardiology.
Dickstein K. Guidelines for the diagnosis and treatment of acute and chronic heart failure / K. Dickstein, A. Cohen-Solal // Eur Heart J. – 2008. –No 29. – p. 2388.
Brugnara C. Hematologic aspects of kidney disease / C. Brugnara, K. Eckardt. – Philadelphia, 2011. –2800 p. – (Taal MW, ed. Brenner and Rector’s The Kidney).
Filippatos G. International registry to assess medical practice with longitudinal observation for Treatment of Heart Failure (REPORT-HF): rationale for and design of a global registry. / G. Filippatos, S. Khan, A. Ambrosy // Eur J Heart Fail. – 2015. –No 17. – p. 533.
Cohen-Solal A. High prevalence of iron deficiency in patients with acute decompensated heart failure / A. Cohen-Solal, T. Damy, S. Kerebel. // Eur J Heart Fail. – 2014. –No 16. – p. 789–91.
Nanas J. Etiology of anemia in patients with advanced heart failure / J. Nanas, C. Matsouka, D. Karageorgopoulos., 2006. – 2568 p.
Auerbach M. Single-dose intravenous iron for iron deficiency: a new paradigm. / M. Auerbach, T. Deloughery // Hematology Am Soc Hematol Educ Program. – 2016. –No. 57. – p. 234.
Dickstein K. Guidelines for the diagnosis and treatment of acute and chronic heart failure [Electronic resource] / K. Dickstein, A. Cohen-Solal, G. Filippatos // Eur Heart J. – 2008.
Anker S. D. Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency [Electronic resource] / S. D. Anker, C. J. Comin // N Engl J Med. – 2009.
Niehaus E. D. Repletion of Iron Stores With the Use of Oral Iron Supplementation in Patients With Systolic Heart Failure / E. D. Niehaus, R. Malhotra, D. Cocca-Spofford. // J Card Fail. – 2015. –No. 21. –p. 234–35.
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