LATE COMPLICATIONS AFTER THERAPY IN PATIENT WITH HODGKIN'S LYMPHOMA
Abstract
During the past five decades, dramatic progress has been made in the development of curative therapy for hematologic malignancies, including Hodgkin’s Lymphoma (HL). The therapy responsible for this survival can also produce adverse long-term health-related outcomes, referred to as «late effects», which manifest months to years after completion of cancer treatment.
The purpose of this report is to pay attention to the problem of late complications, which develop in distant period after combined therapy of HL on example of illustrative clinical case.
Patients, who have been treated for Hodgkin's disease, despite being cured of their malignancy, may develop iatrogenic complications that lead to premature mortality. A substantial excess risk of mortality may be attributable to second cancers and cardiac diseases. Multitude of patients has been treated with anthracyclines or chest radiation, both of which may cause cardiovascular and kidney damage. The frequency of long-term complications in patients treated for Hodgkin's disease makes continued follow-up an important part of their care. This follow-up should include efforts to prevent morbidity and mortality by early diagnosis and attention to risk factors. Future treatment regimens for Hodgkin's disease should be designed attempting to minimize these complications.
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