ROLE OF NESFATIN-1 IN MAINTAINING CARBOHYDRATE HOMEOSTASIS IN HYPERTENSIVE PATIENTS
The aim of this study is to analyze changes in the nesfatin-1 level in hypertensive patients depending on the carbohydrate profile parameters. 83 hypertensive patients aged 33 to 77 years were examined. Nesfatin-1 levels were determined by enzyme immunoassay method. Hypertensive patients have significantly higher levels of adipocytokine than healthy people. Results of data analyses may indicate a possible antihyperglycemic and insulinotropic effect of nesfatin-1 in hypertensive patients with normoglycemia or prediabetes. Confirmation of these processes requires a special study.
Kovalenko V. M. Sertsevo-sudinni hvorobi: medichno-sotsialne znachennya ta strategiya rozvitku kardiologiyi v Ukrayini / V. M. Kovalenko, A. P. Dorogoy // Ukrayinskiy kardiologichniy zhurnal. – 2016. – Dod. 3. – S. 5–14.
Bratus V. V. Ozhirenie, insulinorezistetnost, metabolicheskiy sindrom: fundamentalnyie i klinicheskie aspektyi / V. V. Bratus, T. V. Talaeva, V. A.Shumakov; pod red. V. N. Kovalenko. – K.: Chetverta hvilya, 2009. – 413 s.
Oh-I S. Identification of nesfatin-1 as a satiety molecule in the hypothalamus / S. Oh-I, H. Shimizu // Nature. – 2006. – № 443. – P. 709–712.
Goebel-Stengel M. Central and peripheral expression and distribution of NUCB2/nesfatin-1 / M. Goebel-Stengel, L. Wang // Current Pharmaceutical Design. – 2013. – № 19. – P. 6935–6940.
Nakata M. Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+) influx through L-type channels in mouse islet beta-cells / M. Nakata, K. Manaka, S. Yamamoto [et al.] // Endocrine Journal. – 2011. – № 58. – P. 305–313.
Li Z. Peripheral effects of nesfatin-1 on glucose homeostasis / Z. Li, L. Gao, H. Tang [et al.] // PLoS ONE. – 2013. – № 8(8). – e71513.
Shimizu H. Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism / H. Shimizu, S. Oh-I // Endocrinology. – 2009. – № 150. – P. 662–671.
Tanida M. Nesfatin-1 stimulates renal sympathetic nerve activity in rats / M. Tanida, M. Mori // Neuroreport. – 2011. – № 22. – P. 309–312.
Liu F. Decreased plasma nesfatin-1 level is related to the thyroid dysfunction in patients with type 2 diabetes mellitus / F. Liu, Q. Yang, N. Gao [et al.] // Journal of Diabetes Research. – 2014. – № 2014. – 128014.
Li J. B. Effects of aging on the plasma levels of nesfatin-1 and adiponectin / J. B. Li, M. Nishida, K. Kaimoto [et al.] // Biomedical Reports. – 2014. – № 2. – P. 15–156.
Demidenko G. V. DisfunktsIya endoteliyu yak faktor rozvitku insulinorezistentnosti u hvorih na gipertonichnu hvorobu / G. V. Demidenko // Meditsina sogodni i zavtra. – 2012. – № 3–4. – S. 75–81.
Lastra G. Type 2 diabetes mellitus and hypertension: An update / G. Lastra, S. Syed, L. R. Kurukulasuriya [et al.] // Endocrinology and metabolism clinics of North America. – 2014. – № 43(1). – S. 103–122.
Yosten G. L. Nesfatin-1 exerts cardiovascular actions in brain^ possible interaction with the central melanocortin system / G. L. Yosten, W. K. Samson // American journal of physiology. Regulatory, integrative and comparative physiology. – 2009. – № 297(2). – P. 330–336.
Yamawaki H. A novel adipocytokine? Nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats / H. Yamawaki, M. Takahashi, M. Mukohda [et al.] // Biochemical and Biophysical Research Communications. – 2012. – № 418(4). – P. 676–681.
Ramanjaneya M. Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity / M. Ramanjaneya, J Chen, J. E. Brown [et al.] // Endocrinology. – 2010. – № 151. – 3169–3180.
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