THE NEUROHUMORAL EFFECTS OF METOCLOPRAMIDUM

  • S.N. Panchuk
  • V.B. Zhukova
  • I.A. Bondarenko
  • H.N. Pasko
  • I.V. Solovjova
Keywords: neurohumoral regulation, heart rate variability, metoclopramidum

Abstract

Neurohumoral effects of metoclopramidum on 18 healthy volunteers were studied with the help of heart rate variability technology (HRV) under acute pharmacological test conditions. The obtained results indicated that metoclopramidum decreases the total power of neurohumoral regulation (NHR) mostly by depressing sympathetic activity and least -  parasympathetic one. The degree of the preparation effect on HRV indexes was determined by the initial sympathovagal balance of the volunteers. Metoclopramidum did not show the ability to modify the directions of HRV parameter changes in conditions of active tilt test. The preparation effect was limited by more significant deposit decrease of a parasympathetic component  with a shift of autonomic balance towards sympathetic influences. The above effect was not determined by the initial values of sympathovagal balance. The determined individuality of the neuroregulatory systems response to metoclopramidum intake requires its preliminary testing in acute pharmacological test. The optimal management of a patient requires planning of the dose and regimen of a medication intake.

Downloads

Download data is not yet available.

References

1. Complete heart block induced by intravenous metoclopramide /Huerta Blanco R, Hernandez Cabrera M, Quinones Morales I, Cardenes Santana MA.// An. Med Interna. 2000. Apr. V. 17(4). P. 222-223.

2. Hursidic-Radulovic A. Hypertensive crisis caused by metoclopramide. // Lijec Vjesn. 2000. Jan-Feb. V.122 (1-2). P. 30-31.

3. Is the QT interval an indicator of autonomic state? / Murakawa Y, Yamashita T, Ajiki K, Suzuki J, Hayami N, Fukui E, Kasaoka Y, Omata M, Nagai R.// Jpn Heart J. 2000. Nov. V. 41(6). P. 713-721.

4. Mohammad S., Zhengfeng Z., Qiuming G., January G.T. Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride. // Am. J. Physiol. 273 (Heart Circ. Physiol. 42). 1997. P. H2534-H2538.

5. Wysowski D.K., Bacsanyl J. Cisapride and fatal arrythmia. // N.Engl. J. Med. 1996. V. 335. P. 290-291.
How to Cite
Panchuk, S., Zhukova, V., Bondarenko, I., Pasko, H., & Solovjova, I. (1). THE NEUROHUMORAL EFFECTS OF METOCLOPRAMIDUM. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (2), 61-67. Retrieved from https://periodicals.karazin.ua/medicine/article/view/7435
Issue
No. 2 (2001)
Section
Clinical research

The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.