OPIATERGIC MECHANISMS OF SPONTANEOUS AND INDUCED LOCOMOTOR ACTIVITY DETERIORATIONS IN RATS UNDER THE INFLUENCE OF TRANSCRANIAL MAGNETIC STIMULATION
Abstract
In acute experiments on Wistar rats it was shown that transcranial magnetic stimulation (TMS) (1,5 Тl, 20 impulses, 30 min from the moment of cessation of TMS) is followed by the decreasing of those indices which were determined in «open field» test. Namely, the number of crossed squares as well as the number of rearings were substantially reduced. Naloxon (1,0 and 10,0 mg/kg, i.p.) induced dosage-depended protective action with regard to TMS-induced effects upon animal's behaviour. The enlargement of opiate-induced components of posture-tonic reactions- explozivness, exophtalm, adduction of extremities, decreasing of pain-induced reactions, increasing of tail tonus, loosing of the ability to hold on the rode and grasping of the pencil were seen. Mentioned behavioral reactions were blocked by naloxon (10,0 mg/kg, i.p.). The conclusion was made on the activation fo kapa-opiate receptors in the course of TMS.
Downloads
References
2. Кресюн В.И., Годлевский Л.С., Антоненко П.Б., и др. // В сб.: Современные аспекты лечения эпи-лепсии. (Тезисы конф.). Одесса. 2001. 2001. С. 21-22.
3. Caldecott-Hazard S., Engel J. // Prog. Neuro-psychopharmacol. Biol. Psychiatry. 1987. Vol.11. P.389-418.
4. Myslobodsky M., Kofman O., Mintz M. // Epilepsia. 1981. Vol.27. №5. P.559-568.
5. Shandra A.A., Godlevsky L.S., Mazarati A.M., et al. // Brain Res. Bull. 1994. Vol.35. №4. P. 285-287.
6. Tortella F.C., Long J.B., Hong J.S., et al. // Convul. Ther. 1989. Vol.5. №1. P. 261-273.
7. Tergau F. // Lancet. 1999. V. 353. June. P. 2209.
8. Levkovitz Y., Marx J., Grisaru N., et al. // J. Neurosci. 1999. V.19. №8. P. 3198- 3203.
9. Ziemann U., Steinhoff B.J., Tergau F., et al. // Epilepsy Res. 1998. V.30. №1. P.11- 30.
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
