INFLUENCE OF LONG-TERM THERAPY OF INHALATION GLUCOCORTICOSTEROIDS AND BRONCHIAL SPASMOLYTICS ON THE INDEXES OF RESPIRATORY FUNCTION AND HEART RATE VARIABILITY IN PATIENTS WITH BRONCHIAL ASTHMA WITH AN INITIALLY DIFFERENT VOLUMES OF THE FORCED EXPIRATORY VOLUME FOR 1 SECOND
Abstract
Aim of the study of long-term inhalation glucocorticosteroids and bronchial spasmolytics therapy influence on the RF and HRV indexes in patients with bronchial asthma (BA) with an initially different forced expiratory volumes for 1 second for development of proposals on the improvement of therapy and BA control. 140 patients (58 men and 82 women) with I-IV degreeof BA were examined in ambulatory terms. Mean age – 48±2,5 years. Duration of disease – 9,3±8,1 years. RF was estimated by computer spirograph «SpiroSom» XAI, were taken into account: respiration rate frequency (RRF), forced expiratory volume for 1st, 2nd and 3rd seconds (FEV1,2,3), momentary volume speeds of the forced exhalation in the moment of 25, 50, 75% MEFL (MVS25,50,75). For the heart rate variability (HRV) analysis computer electrocardiograph «Cardiolab+» XAI was used; heart rate in 1 minute (HR); total power of spectrum (TP); spectrum power in area of high and low-frequencies (LF, HF) and relation of low and high frequencies spectrum regions powers (LF/HF) were estimated. Results showed that long-term BA therapy has positive influence on the RF indexes (FEV1,2,3, MVS25,50,75) and HRV(ТР, LF,HF, LF\HF) in all patients groups. The increase of the RF indexes depends on the initial FEV1 value and is most marked in the group of patients with FEV 1 values 80-60%. Interrelation between the FEV1 and HRV TP value in patients with BA confirms meaningfulness of regulatory mechanisms in breathing for state of health of patients and results of medical treatment.
Downloads
References
2. Авдеев С.Н., Чучалин А.Г. // Тер.арх. - 2000. - № 2. - С. 75-78.
3. Берсенев Е.Ю., Соболев А.М., Баевский Р.М. // Пульмонология. - 2001. - № 3. - С. 99-107.
4. Давыдова Е.В., Смольникова О.А., Зарипова Г.Р., и др. // Пульмонология. - 1999. - № 5. - С. 67-72.
5. Иванов В.Н., Фильшина Е.В., Драчук Е.Б., и др. // Пульмонология. - 2002. - № 5. - С. 76-81.
6. Марченко В.Н., Трофимов В.И., Александрин В.А., и др. // Пульмонология. - 2003. - № 6.- С.13-17.
7. Миронов В.А., Драчук Е.Б., Фильшина Е.В., и др. // РМЖ - 2001. - № 9. - С. 18-25
8. Фещенко Ю. И., Яшина Л. А., Полянская М. А., и др. Обструктивные заболевания легких: Образо-вательная программа для врачей. -К.: - 2004. - 287 с.
9. Яблучанский НИ, Мартыненко АВ, Исаева АС. Основы практического применения неинвазивной технологии исследования регуляторных систем человека. - Харьков: Основа. - 2000. - 88 с.
10. Яблучанский Н.И., Мартыненко А.В., Исаева А.С., и др. Исследуем регуляторные процессы. Для настоящих врачей. - Донецк: ЧП Бугасова. - 2005. - 196 с.
11. Heindl S., Lehnert М., Criée C-P., et. al. // Am. J. Respir. Crit. Care Med. – 2001.- Vol. 164. № 4. August 2001. - Р. 597-601
12. Antczak A., Kurmanowska Z., Kasielski M., et. al. // Respir. Med. - 2000. - Vol. 94. - № 5. - P. 416-421
13. Bellamy D, Harris T. // Eur Respir J. – 2004. - № 24 (Suppl 48). - Р. 83-87.
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
