THE MAINTENANCE OF PLASMINOGEN ACTIVATOR INHIBITOR-1 IN BLOOD SERUM IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Keywords:
type 2 diabetes mellitus, cardiovascular complications, fibrinolytic activity, plasminogen activator inhibitor-1
Abstract
The maintenance of plasminogen activator inhibitor-1 (PAI-1) in blood serum in patients with type 2 diabetes mellitus of the senior age group with long term of disease and the role of this index in the development of cardiovascular complications were studied. The statistically significant dependence of PAI-1 on arterial hypertension, fibrinogen, triglycerides, very low density lipoproteides, body weight index and insulin resistance was determined.
It was shown, that PAI-1 was a significant additional risk factor in the development of cardiovascular diseases in patients with type 2 diabetes mellitus.
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References
1. Morgan Christopher Ll., Currie Craig J., Peters John R. // Diabetes Care. - 2000. - Vol. 23. - № 8. - Р. 1103-1107.
2. Ridker P.M. // Ann Intern Med. - 1999. - Vol. 130. - P. 933-937.
3. J.J. Shin, J. Rokhman, A. Farag, et al. // Minerva Med. - 2003. - Vol. 94. - № 6. - P. 401-408.
4. T.K. Nordt, K. Peter, J. Ruef, et al. // Thromb Haemost. - 1999. - Vol. 82. - P. 14-18.
5. Rocha E., Paramo J.A. // Fibrinolysis. - 1994. - Vol. 8. - P. 294-303.
6. Kohler H.P., Grant P.J. // N.Engl. J. Med. - 2000. - Vol. 342. - P. 1792-1801.
7. Barton E. Sobel, Douglas J. // Atherosclerosis, thrombosis and vascular biology. - 2003. - Vol. 23. - P. 1979-1801.
8. S.G. Thompson, J. Kienast, S.D.M. Pyke, et al. // N.Engl. J. Med. - 1995. - Vol. 332. - P. 635-641.
9. K. Mainberg, S. Yusuf, H.S. Gerstein, et al. // Circulation. - 2000. - Vol. 102. - P. 1014-1019.
10. Juhan-Vague I., Alessi M.C. // Thromb Haemost. - 1997. - Vol. 78. - P. 656-660.
11. Julian-Vague I., Thompson S.G., Jespersen J. // Arterioscler Thromb. - 1993. - Vol. 13. - P. 1865-1873.
12. Festa A., D'Agostino R.Jr., Mykkanen L., et al. // Arterioscler. Thromb. Vase Biol. - 1999. - Vol. 19. - P. 562-568.
13. Sobel B.E., Neimane D., Mack W.J., et al. // Coron Artery Dis. - 2002. - Vol. 13. - P. 275-28l.
14. Nugent A.P. // Nulr Ball. - 2004. - Vol. 29. - № 1. - P. 36-43.
15. Gürlek Alper, Bayraktar Miyase, Kirazli Serafettin // Diabetes Care. - 2000. - Vol. 23. - №1. - P. 86-92.
16. Vatchapapan Umpaichitra, M. Mahmood Hussain, Salvador Castells // Pediatric Research. - 2005. - Vol. 58. - P. 483-487.
17. A. Pandolfi, D. Cetrullo, R. Polishuck, et al. // Arteriosclerosis Thrombosis and Vascular Biology. - 2001. - Vol. 21. - P. 1378-1382.
18. B.E. Sobel, J. Woodcock-Mitchell, D.J. Schneider, et al. // Curculation. - 1998. - Vol. 97. - P. 2213-2221.
19. Nordt T.K., Rlassen K.J., Scfmeider D.J., et al. // Arterioscler. Thromb. - 1993. - Vol. 13. - P. 1822-1828.
20. Sobel B.E. // Proc. Assoc. Am Physicians. - 1999. - Vol. 111. - P. 313-318.
21. J.B. Meigs, M.A. Mittleman, D.M. Nathan, et al. // JAMA. - 2000. - Vol. 283. - P. 221-228.
22. Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor-1 in blood in normal hunian / J. Cales-Escandon, S. Mizza et al. // Subjects. Diabetes. – 1998. – Vol. 47. – P. 290-293.
23. Y. Aso, S. Matsumoto, Y. Fujiwara, et al. // Metabolism - 2002. - Vol. 51. - P. 471-476.
24. Alessi M.C., Peiretti F., Morange P. et al. // Diabetes. - 1997. - Vol. 46. - P. 860-867.
25. N.Iwai, H.Shimoike, Y.Nakamura et al. // Atherosclerosis. - 1998. - Vol. 136. - № 1. - P. 109-114.
26. L. Iacovielio, F. Burzotta, A. Di Castelnuovo, et al. // Tromb Hemost. - 1998. - Vol. 80. - P. l029-1030.
27. W.T. Cefalu, D.J. Schneider, H.E. Carlson, et al. // Diabetes Care. - 2002. - Vol. 25. - P. 2123-2128.
28. A. Panahloo, V. Mohamed-AIi, C. Andres, et al. // Metabolism. - 1998. - Vol. 47. - P. 637-643.
29. Wu Bо. Han Ping, Liu Ying-min // Chin. J. New Drugs and Clin. Rem. - 2004. - Vol. 23. -№ 12. - P. 836-838.
30. Mc Cully K.S. // Amer. J. Phatology. - 1969. - Vol. 56. - P. 111-128.
31. Сидоренко Г.И., Мойсеенок А.Г., Колядко М.Г. // Кардиология. - 2001. - № 1. - С. 6-11.
32. Коваль Е.А, Каплан П.А. // Международ. мед. журн. - 2004. - № 1. - С. 15-17.
33. Мамедов М.Н., Метельская В. // Кардиология. - 2000. - № 2. - С. 83-89.
2. Ridker P.M. // Ann Intern Med. - 1999. - Vol. 130. - P. 933-937.
3. J.J. Shin, J. Rokhman, A. Farag, et al. // Minerva Med. - 2003. - Vol. 94. - № 6. - P. 401-408.
4. T.K. Nordt, K. Peter, J. Ruef, et al. // Thromb Haemost. - 1999. - Vol. 82. - P. 14-18.
5. Rocha E., Paramo J.A. // Fibrinolysis. - 1994. - Vol. 8. - P. 294-303.
6. Kohler H.P., Grant P.J. // N.Engl. J. Med. - 2000. - Vol. 342. - P. 1792-1801.
7. Barton E. Sobel, Douglas J. // Atherosclerosis, thrombosis and vascular biology. - 2003. - Vol. 23. - P. 1979-1801.
8. S.G. Thompson, J. Kienast, S.D.M. Pyke, et al. // N.Engl. J. Med. - 1995. - Vol. 332. - P. 635-641.
9. K. Mainberg, S. Yusuf, H.S. Gerstein, et al. // Circulation. - 2000. - Vol. 102. - P. 1014-1019.
10. Juhan-Vague I., Alessi M.C. // Thromb Haemost. - 1997. - Vol. 78. - P. 656-660.
11. Julian-Vague I., Thompson S.G., Jespersen J. // Arterioscler Thromb. - 1993. - Vol. 13. - P. 1865-1873.
12. Festa A., D'Agostino R.Jr., Mykkanen L., et al. // Arterioscler. Thromb. Vase Biol. - 1999. - Vol. 19. - P. 562-568.
13. Sobel B.E., Neimane D., Mack W.J., et al. // Coron Artery Dis. - 2002. - Vol. 13. - P. 275-28l.
14. Nugent A.P. // Nulr Ball. - 2004. - Vol. 29. - № 1. - P. 36-43.
15. Gürlek Alper, Bayraktar Miyase, Kirazli Serafettin // Diabetes Care. - 2000. - Vol. 23. - №1. - P. 86-92.
16. Vatchapapan Umpaichitra, M. Mahmood Hussain, Salvador Castells // Pediatric Research. - 2005. - Vol. 58. - P. 483-487.
17. A. Pandolfi, D. Cetrullo, R. Polishuck, et al. // Arteriosclerosis Thrombosis and Vascular Biology. - 2001. - Vol. 21. - P. 1378-1382.
18. B.E. Sobel, J. Woodcock-Mitchell, D.J. Schneider, et al. // Curculation. - 1998. - Vol. 97. - P. 2213-2221.
19. Nordt T.K., Rlassen K.J., Scfmeider D.J., et al. // Arterioscler. Thromb. - 1993. - Vol. 13. - P. 1822-1828.
20. Sobel B.E. // Proc. Assoc. Am Physicians. - 1999. - Vol. 111. - P. 313-318.
21. J.B. Meigs, M.A. Mittleman, D.M. Nathan, et al. // JAMA. - 2000. - Vol. 283. - P. 221-228.
22. Induction of hyperinsulinemia combined with hyperglycemia and hypertriglyceridemia increases plasminogen activator inhibitor-1 in blood in normal hunian / J. Cales-Escandon, S. Mizza et al. // Subjects. Diabetes. – 1998. – Vol. 47. – P. 290-293.
23. Y. Aso, S. Matsumoto, Y. Fujiwara, et al. // Metabolism - 2002. - Vol. 51. - P. 471-476.
24. Alessi M.C., Peiretti F., Morange P. et al. // Diabetes. - 1997. - Vol. 46. - P. 860-867.
25. N.Iwai, H.Shimoike, Y.Nakamura et al. // Atherosclerosis. - 1998. - Vol. 136. - № 1. - P. 109-114.
26. L. Iacovielio, F. Burzotta, A. Di Castelnuovo, et al. // Tromb Hemost. - 1998. - Vol. 80. - P. l029-1030.
27. W.T. Cefalu, D.J. Schneider, H.E. Carlson, et al. // Diabetes Care. - 2002. - Vol. 25. - P. 2123-2128.
28. A. Panahloo, V. Mohamed-AIi, C. Andres, et al. // Metabolism. - 1998. - Vol. 47. - P. 637-643.
29. Wu Bо. Han Ping, Liu Ying-min // Chin. J. New Drugs and Clin. Rem. - 2004. - Vol. 23. -№ 12. - P. 836-838.
30. Mc Cully K.S. // Amer. J. Phatology. - 1969. - Vol. 56. - P. 111-128.
31. Сидоренко Г.И., Мойсеенок А.Г., Колядко М.Г. // Кардиология. - 2001. - № 1. - С. 6-11.
32. Коваль Е.А, Каплан П.А. // Международ. мед. журн. - 2004. - № 1. - С. 15-17.
33. Мамедов М.Н., Метельская В. // Кардиология. - 2000. - № 2. - С. 83-89.
How to Cite
Kravchun, N. (1). THE MAINTENANCE OF PLASMINOGEN ACTIVATOR INHIBITOR-1 IN BLOOD SERUM IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (13), 100-104. Retrieved from https://periodicals.karazin.ua/medicine/article/view/7089
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