ANEMIA OF CHRONIC DISEASE

  • M.T. Vatutin
  • N.V. Kalinkina
  • G.S. Smyrnova
Keywords: anemia of chronic disease

Abstract

The represented analysis of literature is dedicated to the problem of anemia development at different chronic diseases, which occupies the second place among all anaemias. In spite of simplicity of anaemic syndrome detection, at diagnostics of anaemia of chronic disease (ACD) quite often there are complications, as it is not an independent nosologic unit, but display of other disease. We give consideration to pathogenesis, role of proinflammatory cytokines, genetic and other factors, which induced anemia of chronic disease. We investigated the role of those medicines, which is used in the treatment of this pathology and improved quality of life.

Downloads

Download data is not yet available.

References

1. Cartwright G.E. The anemia of chronic disorders / G.E. Cartwright // Semin Hematol.  1966.  № 3. – Р. 351-375.

2. Nissenson A.R. Anemia: not just an innocent bystander? / A.R. Nissenson, L.T. Goodnough, R.W. Dubois // Arch Intern Med. 2003.  № 163. – Р. 1400-1404.

3. Melnikova I. Anaemia therapies / I. Melnikova //Nat Rev Drug Discov. – 2006.  № 5. – Р. 627-628.

4. McClellan W. The prevalence of anaemia in patients with chronic kidney disease / W. McClellan, S.L. Aronoff, W.K. Bolton // Curr Med Res Opin. – 2004.  № 20. – Р. 1501-1510.

5. Felker G.M. Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure / G.M. Felker, W.A. Gattis, J.D. Leimberger // Amer. J. Cardiology. – 2003. – № 5. – P. 625-628.

6. Meyer T.E. Anemia in heart failure / T.E. Meyer // Curr. Cardiol. Rep. – 2003. – № 3. – P. 213-214.

7. Peeters H.R. Course and characteristics of anaemia in patients with rheumatoid arthritis of recent onset / H.R. Peeters, M. Jongen-Lavrencic // Ann Rheum Dis. – 1996.  № 55. – Р. 162-168.

8. Wolfe F. Anemia and renal function in patients with rheumatoid arthritis / F. Wolfe, К. Michaud // J Rheumatol. – 2006.  № 33. – Р. 1467-1468.

9. Özatli D. Erythrocytes: Anemias in Chronic Liver Diseases / D. Özatli, A.S. Köksal, I.C. Haznedaroglu // Hematology.- 2000.  № 5. – Р. 69-76.

10. Voulgarelis M. Anaemia in systemic lupus erythematosus:aetiological profile and thе role of erythropoietin / М. Voulgarelis, S.I.G. Kokori, J.P.A Ioannidis // Ann. Rheum. Dis. – 2000.  № 59. – Р. 217–222.

11. Giannouli S. Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment / S. Giannouli, М. Voulgarelis, P.D. Ziakas, A.G.Tzioufas // Ann Rheum Dis. – 2006.  № 65.  Р. 144-148.

12. Новик А.А. Анемии (от А до Я) руководство для врачей /
А.А.Новик, А.Н. Богданов А.Н.  Санкт-Петербург: Нева, 2004.

13. Sikole А. Pathogenesis of anaemia in hyperparathyroidism / А. Sikole // Internist (Berl). – 2000.  № 54. – Р. 236-238.

14. Ellegala D.B. Anemia, testosterone, and pituitary adenoma in men / D.B. Ellegala, T.D. Alden, D.E. Couture // J Neurosurg. – 2003.  № 56. – Р. 974-977.

15. Nishioka H. Hypopituitarism and anemia: effect of replacement therapy with hydrocortisone and/or levothyroxine / Н. Nishioka, J. Haraoka // J Endocrinol Invest. – 2005.  № 28. – Р 528-533.

16. Thomas М.С. Functional erythropoietin deficiency in patients with Type 2 diabetes and anaemia / М.С. Thomas, С. Tsalamandris, R. Macisaac // Diabet Med. – 2006.  № 23. – Р. 502-509.

17. Salah N. Prevalence and type of anaemia in young Egyptian patients with type 1 diabetes mellitus / N. Salah, F.A. El Hamid, S. Abdelghaffar / East Mediterr Health J. – 2005.  № 5. – Р. 959-967.

18. Melis M. Correlations between neoadjuvant treatment, anemia, and perioperative complications in patients undergoing esophagectomy for cancer / М. Melis, J.M. McLoughlin, Е.М. Dean // J Surg Res. – 2009.  № 153. – Р.114-120.

19. Weiss G. Pathogenesis and treatment of anaemia of chronic disease / G. Weiss // Blood Rev. – 2002.  № 16. – Р. 87-96.

20. Li H. Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS / Н. Li, M.J. Rose, L. Tran, J. Zhang, L.P. Miranda, С.А. James, B.J. Sasu // J Pharmacol Toxicol Methods. – 2009.  № 179. – Р. 171-180.

21. Pigeon C. A new mouse liver specific protein homologous to human antibacterial peptid hepcidin is overexpressed during iron overload / С. Pigeon, G. Ilyin, В. Courselaud // J. Biol. Chem. – 2001.  № 276. – Р. 7811-7819.

22. Nemeth E. IL6 mediates hypoferremia inducing the synthesis of the iron regulatory hormone hepcidin / Е. Nemeth, S. Rivera, V.J. Gabajan // V.J. Clin. Inv. – 2004.  № 113. – Р. 1271–1276.

23. Knutson M.D. Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin / M.D. Knutson, М. Oukka, L.M. Koss, F. Aydemir, М. Wessling-Resnick // Proc Natl Acad Sci U S A. – 2005.  № 102. – Р. 1324-1328.

24. Chaston T. Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells / Т. Chaston, В. Chung, М. Mascarenhas, J. Marks // Gut. – 2008.  № 57. – Р. 374-382.

25. Dallalio G. Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations / G. Dallalio, Е. Law, R.T. Means // Blood.  2006.  № 107. – Р. 2702–2704.

26. Lang F. Mechanisms and significance of eryptosis / F. Lang, K.S. Lang, Р.А. Lang // Antioxid Redox Signal. – 2006.  № 8. – Р. 1183-1192.

27. Moldawer L.L. Cachectin/tumor necrosis factor-alpha alters red blood cell kinetics and induces anemia in vivo / L.L. Moldawer, М.А. Marano, Н. Wei // FASEB J. – 1989.  № 3. – Р. 1637–1643.

28. Kullich W. Effects of the chemokine MIP-1alpha on anemia and inflammation in rheumatoid arthritis / W. Kullich, F. Niksic, K. Burmucic // Z Rheumatol. – 2002.  № 61. – Р. 568-576.

29. Zhu Y. The correlation of cytokines TNF alpha, IFN-gamma, Epo with anemia in rheumatoid arthritis / Y. Zhu, D. Ye, Z. Huang // Zhonghua Xue Ye Xue Za Zhi. – 2000.  № 21. – Р. 587-590.

30. Papadaki H.A. Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-alpha antibody therapy / Н.А. Papadaki, H.D. Kritikos, V. Valatas // Blood. – 2002.  № 100. – Р. 474-482.

31. Means R.T. Recent developments in the anemia of chronic disease / R.T. Means // Curr. Hematol. Rep.  2003.  № 2.  Р. 116-121.

32. Wang C.Q. Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development / C.Q. Wang, К.В. Udupa, D.A. Lipschitz // J Cell Physiol. – 1995.  № 162. – Р. 134–138.

33. Saravana S. Anemia of chronic disease in patients with rheumatoid arthritis-use of zinc protoporphyrin (ZPP) levels / S. Saravana, А. Rai // J Rheumatol. – 2007.  № 34. – Р. 446.

34. Margetic S. Soluble transferrin receptor and transferrin receptor-ferritin index in iron deficiency anemia and anemia in rheumatoid arthritis / S. Margetic, Е. Topic, D.F. Ruzic // Clin Chem Lab Med. – 2005.  № 43. – Р. 326-331.

35. Fitzsimons E.J. The anaemia of chronic disease : Remains hard to distinguish from iron deficiency anaemia in some cases / E.J. Fitzsimons, J.H. Brock //BMJ. – 2001.  № 322. – Р. 811–812.

36. Koulaouzidis A. A ferritin level <50 microg/L is frequently consistent with iron deficiency / А. Koulaouzidis, R. Cottier, S. Bhat, Е. Said, B.D. Linaker, А.А. Saeed // Eur J Intern Med.  2009.  № 20. – Р. 168-170.

37. Davidson A. Red cell ferritin content: a re-evaluation of indices for iron deficiency in the anaemia of rheumatoid arthritis / А. Davidson, М.В. Van der Weyden, Н. Fong // Br Med J.  1984.  № 289. – Р. 648–650.

38. Pavai S. Soluble transferrin receptor, ferritin and soluble transferrin receptor--Ferritin index in assessment of anaemia in rhaeumatoid arthritis / S. Pavai, S. Jayaranee, S. Sargunan //Med J Malaysia. – 2007.  № 62. – Р. 303-307.

39. Das Gupta A. High serum transferrin receptor level in anemia of chronic disorders indicates coexistent iron deficiency / А. Das Gupta, А. Abbi // Am J Hematol. – 2003.  № 72. – Р. 158-161.

40. Arndt U. Correction of iron-deficient erythropoiesis in the treatment of anemia of chronic disease with recombinant human erythropoietin / U. Arndt, J.P. Kaltwasser, R. Gottschalk // Ann Hematol. – 2005.  № 84. – Р. 159-166.

41. Kaltwasser J.P. Effect of recombinant human erythropoietin and intravenous iron on anemia and disease activity in rheumatoid arthritis / J.P. Kaltwasser, U. Kessler, R. Gottschalk, G. Stucki, B. Moller // J. Rheumatol. – 2001.  № 28. – Р. 2430-2436.

42. NKF-K/DOQI Clinical Practice Guidelines for anemia of chronic kidney disease: update 2000 // Am. J. Kidney Dis. – 2001.  № 37. – Р. 182-238.

43. Ruiz-Argüelles G.J. Ineffectiveness of oral iron hydroxide polymaltose in iron-deficiency anemia / G.J. Ruiz-Argüelles, А. Díaz-Hernández, С. Manzano // Hematology. – 2007.  № 12. – Р. 255-256.

44. Reynoso-Gómez Е. Safety and efficacy of total dose intravenous iron infusion in the treatment of iron-deficiency anemia in adult non-pregnant patients / Е. Reynoso-Gómez, V. Salinas-Rojas, А. Lazo- Langner // Rev Invest Clin. – 2002.  № 54. – Р. 12-20.

45. Weinberg E.D. Iron loading and disease surveillance / E.D. Weinberg // Emerg Infect Dis. -1999.  № 5. – Р. 346-352.

46. Weiss G., Goodnough L.T. Anemia of Chronic Disease / G. Weiss, L.T. Goodnough // New. Eng. J. Med. -2005.  № 10. – Р. 1011-1023.

47. Bhattacharya N. Placental umbilical cord whole blood transfusion to combat anemia in the background of advanced rheumatoid arthritis and emaciation and its potential role as immunoadjuvant therapy / N. Bhattacharya // Clin Exp Obstet Gynecol. – 2006.  № 33. – Р. 28-33.

48. Lowenthal R.M., Gill D.S. Twenty-year remission of rheumatoid arthritis in 2 patients after allogeneic bone marrow transplant / R.M. Lowenthal, D.S. Gill // J Rheumatol. – 2006.  № 33. – Р. 812-813.

49. Silverberg D.S. The correction of anemia in patients with the combination of chronic kidney disease and congestive heart failure may prevent progression of both conditions / D.S. Silverberg, D. Wexler, А. Iaina // Clin Exp Nephrol. – 2009.  № 13. – Р. 101-106.

50. Gouva C. Treating anemia early in renal failure patients slows the decline of renal funtion: a randomized controlled trial / С. Gouva, Р. Nikolopoulos, J. Ionnidis, К. Siamopoulos // Kidney Int. – 2004.  № 66. – Р. 753–760.

51. Thomas M.C. Anemia in diabetes: marker or mediator of microvascular disease? / М.С. Thomas // Nat Clin Pract Nephrol.  2007.  № 3. – Р. 20-30.

52. Singh A.K. CHOIR Investigators. Correction of anemia with epoetin alfa in chronic kidney disease / А.К. Singh, L. Szczech, K.L. Tang // N Engl J Med. – 2006.  № 355. – Р. 2085-2098.

53. Strippoli G.F. Haemoglobin and haematocrit targets for the anaemia of chronic kidney disease / G.F. Strippoli, S.D. Navaneethan, J.C. Craig // Cochrane Database Syst Rev.  2006. – 18.  № 4.

54. Li Н. Intravenous iron sucrose in peritoneal dialysis patients with renal anemia / Н. Li, S.Х. Wang // Perit Dial Int. – 2008.  № 28. – Р. 149-154.

55. Coyne D.W. A comprehensive vision for intravenous iron therapy / D.W. Coyne // Am J Kidney Dis. – 2008.  № 5. – Р. 14-20.

56. Kalantar-Zadeh К. Intravenous iron versus erythropoiesis-stimulating agents: friends or foes in treating chronic kidney disease anemia? / К. Kalantar-Zadeh, М. Streja, J.E. Miller, А. Nissenson //Adv Chronic Kidney Dis. – 2009.  № 16. – Р. 143-151.

57. Ferreira S.M. Anemia and renal failure as predictors of risk in a mainly non-ischemic heart failure population / S.M. Ferreira, G.V. Guimarães, F.D. Cruz // Int J Cardiol. – 2008.

58. Glossop J.R. Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes / J.R. Glossop, P.T. Dawes, A.B. Hassell // J Rheumatol. – 2005.  № 32. – Р. 1673-1678.

59. Mitlyng B.L. Use of breath carbon monoxide measurements to assess erythrocyte survival in subjects with chronic diseases / B.L. Mitlyng, J.A. Singh, J.K. Furne // Am J Hematol. – 2006.  № 81. Р. 432-438.

60. Nurmohamed М.Т. Cyclosporin for sulphasalazine-induced aplastic anaemia in a patient with early rheumatoid arthritis / М.Т. Nurmohamed, М. Soesan, М.Н. van Oers // Rheumatology (Oxford). – 2000.  № 39. – Р. 1431-1433.

61. Петров В.А. Анемия и системная красная волчанка: история одного непростого диагноза / В.А. Петров, В.А. Белоглазов, С.Н. Захарова // Український ревматологічний журнал. – 2008.  № 3. – С. 65-70.

62. Tagoe C. Aplastic anemia in systemic lupus erythematosus: a distinct presentation of acquired aplastic anemia? / С. Tagoe, А. Shah, Н. Yee, H.M. Belmont // J Clin Rheumatol. – 2001.  № 7. – Р. 377-383.

63. Dyjas R. Influence of recombinant human erythropoietin (rHuEPO) on plasma levels of selected hormones in females with rheumatoid arthritis / R. Dyjas, M. Bułanowski, R. Ficek // Pol Arch Med Wewn. – 2005.  № 114. – Р. 731-737.

64. Gomard-Mennesson E. Treatment of isolated severe immune hemolytic anaemia associated with systemic lupus erythematosus: 26 cases / E. Gomard-Mennesson, М. Ruivard, М. Koenig // Lupus. – 2006.  № 15. – Р. 223-231.

65. Pivot X. An analysis of potential factors allowing an individual prediction of cisplatin-induced anaemia / Х. Pivot, Е. Guardiola, М. Etienne, А. Thyss, С. Foa, J. Otto, М. Schneider, N. Magné, R.J. Bensadoun, N. Renée, G. Milano // Eur J Cancer. – 2000.  № 36. – Р. 852–857.

66. Гусева С.А. Анемии. / С. Гусева, Я. Гончаров. – К.: Логос, 2004. – 408 с.

67. Christodoulou C. Effects of epoetin-alpha on quality of life of cancer patients with solid tumors receiving chemotherapy / С. Christodoulou, U. Dafni, G. Aravantinos, А. Koutras, Е. Samantas, М. Karina, J. Janinis, Р. Papakostas, D. Skarlos, Н.Р. Kalofonos, G. Fountzilas // Anticancer Res. – 2009.  № 29. – Р. 693-702.

68. Pedrazzoli P. Iron supplementation and erythropoiesis-stimulatory agents in the treatment of cancer anemia / P. Pedrazzoli, G. Rosti, S. Secondino, S. Siena // Cancer. – 2009.  № 115. – Р. 1169-1173.

69. Anand I.S. Heart failure and anemia: mechanisms and pathophysiology / I.S. Anand // Heart. – 2008.  № 13. – Р. 379-386.

70. Westenbrink В.D. Anemia in chronic heart failure: etiology and treatment options / В.D. Westenbrink, R.A. de Boer, А.А. Voors // Curr Opin Cardiol. – 2008.  № 23. – Р. 141-147.

71. Erbayraktar S. Erythropoietin is a multifunctional tissue-protective cytokine / S. Erbayraktar, О. Yilmaz, N. Gökmen, M. Brines // Curr. Hematol. Rep. – 2003. – № 6. – P. 465-470.

72. Núñez М. Incidence of anaemia and impact on sustained virological response in HIV/HCV-coinfected patients treated with pegylated interferon plus ribavirin / М. Núñez, А. Ocampo, К. Aguirrebengoa // J Viral Hepat. – 2008.  № 15. Р. 363-369.

73. Ellegala D.B. Anemia, testosterone, and pituitary adenoma in men / D.B. Ellegala, T.D. Alden, D.E. Couture, M.L. Vance, N.F. Maartens, E.R.Jr. Laws // J Neurosurg. – 2003.  № 98. – Р. 974-977.

74. Sohmiya М. Effect of long-term treatment with recombinant human growth hormone on erythropoietin secretion in an anemic patient with panhypopituitarism / М. Sohmiya, Y. Kato // J Endocrinol Invest. – 2000.  № 23. – Р. 31-36.

75. Kazmi W.H. Anemia: an early complication of chronic renal insufficiency / W.H. Kazmi // Am J Kidney Dis. – 2001.  № 38. – Р. 803–812.

76. Benjilali L. Pernicious anemia in a young man with systemic lupus erythematosus / L. Benjilali, Z. Tazi-Mezalek, Н. Harmouche, К. Lebbar, М. Aouni, М. Adnaoui, А. Maaouni // Lupus. – 2007.  № 16. – Р. 827-829.

77. Shestakova M.V. Anemia in diabetic nephropathy: prevalence, clinical and pathophysiological aspects / M.V. Shestakova, S.A .Martynov, S.A. Il'in, A.P. Kniazeva, M.Sh. Shamkhalova, N.P. Trubitsyna // Ter Arkh. – 2008.  № 80. – Р. 41-47.
How to Cite
Vatutin, M., Kalinkina, N., & Smyrnova, G. (1). ANEMIA OF CHRONIC DISEASE. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine&quot;, (18), 40-48. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6955
Section
Reviews