INTERLEUKIN-10 AND C-REACTIVE PROTEIN AS PROGNOSTIC MARKERS OF RECCURENT VASCULAR EVENTS AFTER ACUTE CORONARY SYNDROME
Keywords:
acute coronary syndrome, C-reactive protein, interleukin-10, prognostic value, recurrent coronary events
Abstract
Atherosclerotic plague destabilization is defined as strengthening of chronic inflammation process activity and is the reason of acute coronary syndrome (ACS). ACS manifests C-reactive protein (CRP) level increasing. In contrary, anti-inflammatory processes activate – Interleukin-10 (IL-10) level increases. The aim of study was to determine prognostic value of CRP and IL-10 for the ACS outcomes in 6 month after coronary event. The aim realized with the assistance of the using the new coefficient of the reduction level IL-10. This coefficient allows to predict with high probability recurrent coronary events in patients after ACS.
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References
1. Li-ping H. / Early C-reactive protein in the prediction of long-term outcomes after acute coronary syn-drome: a meta-analisys of longitudinal studies / Li-ping H., Xin-yi T., Wen-hua L. // Heart. – 2010. – Vol. 96. – P. 339–346.
2. Ватутин Н.Т. С-реактивный белок и атеросклероз. Часть I. / Н.Т. Ватутин, В.А. Чупина // Укр. баннер. сеть. – 2004.
3. Kushner I. Is high-sensitivity C-reactive protein an effective screening test for cardiovascular risk? / I. Kushner, A.R. Sehgal // Arch. Intern. Med. – 2002. – Vol. 162, № 8. – P. 867–869.
4. C-reactive protein as a risk factor for left ventricular thrombus in patients with acute myocardial infarc-tion / S. Celik, E. Baykan, C. Erdol [еt al.] // Clin. Cardiology. – 2001. – Vol. 24. – P. 615–619.
5. Диагностическое и прогностическое значение маркера системного воспаления С-реактивного протеина у больных с острыми коронарными синдромами / А.Н. Пархоменко, Я.М. Лутай, Г.В. Пономарева [и др.] //Укр. Бан. Сеть. – 2001.
6. Mälarstig А. Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome / A. Mälarstig, P. Eriksson, A. Hamsten [еt al.] // Heart. – 2008. – Vol.94. – P.724–729.
7. TH 1/TH2 imbalance, measured by circulating and intracytoplasmic inflammatory cytokines-immuno-logical alterations in acute coronary syndrome and stable coronary artery disease / P. Szodoray, O. Timar, K. Veres [еt al.] // Scand J Immunol. – 2006. – № 64 (3). – Р. 336–344.
8. Predictive value of CRP and troponin T in patients with unstable angina: a comparative analysis. CAPTURE Investigators. / C. Heeschen, C.W. Hamm, J. Bruemmer [еt al.] // JACC. – 2000. – № 35. – Р. 1535–1542.
9. Динамика воспалительного процесса у больных с острым коронарным синдромом и больных со стабильной стенокардией. Сообщение 1. Биохимические и иммунологические аспекты / В.В. Ку-харчук, К.А. Зыков, В.П. Масенко [и др.] // Кардиологический вестник. – 2007.– Том 02, – № 2.
2. Ватутин Н.Т. С-реактивный белок и атеросклероз. Часть I. / Н.Т. Ватутин, В.А. Чупина // Укр. баннер. сеть. – 2004.
3. Kushner I. Is high-sensitivity C-reactive protein an effective screening test for cardiovascular risk? / I. Kushner, A.R. Sehgal // Arch. Intern. Med. – 2002. – Vol. 162, № 8. – P. 867–869.
4. C-reactive protein as a risk factor for left ventricular thrombus in patients with acute myocardial infarc-tion / S. Celik, E. Baykan, C. Erdol [еt al.] // Clin. Cardiology. – 2001. – Vol. 24. – P. 615–619.
5. Диагностическое и прогностическое значение маркера системного воспаления С-реактивного протеина у больных с острыми коронарными синдромами / А.Н. Пархоменко, Я.М. Лутай, Г.В. Пономарева [и др.] //Укр. Бан. Сеть. – 2001.
6. Mälarstig А. Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome / A. Mälarstig, P. Eriksson, A. Hamsten [еt al.] // Heart. – 2008. – Vol.94. – P.724–729.
7. TH 1/TH2 imbalance, measured by circulating and intracytoplasmic inflammatory cytokines-immuno-logical alterations in acute coronary syndrome and stable coronary artery disease / P. Szodoray, O. Timar, K. Veres [еt al.] // Scand J Immunol. – 2006. – № 64 (3). – Р. 336–344.
8. Predictive value of CRP and troponin T in patients with unstable angina: a comparative analysis. CAPTURE Investigators. / C. Heeschen, C.W. Hamm, J. Bruemmer [еt al.] // JACC. – 2000. – № 35. – Р. 1535–1542.
9. Динамика воспалительного процесса у больных с острым коронарным синдромом и больных со стабильной стенокардией. Сообщение 1. Биохимические и иммунологические аспекты / В.В. Ку-харчук, К.А. Зыков, В.П. Масенко [и др.] // Кардиологический вестник. – 2007.– Том 02, – № 2.
How to Cite
Kopytsa, N., & Lytvyn, O. (1). INTERLEUKIN-10 AND C-REACTIVE PROTEIN AS PROGNOSTIC MARKERS OF RECCURENT VASCULAR EVENTS AFTER ACUTE CORONARY SYNDROME. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (19), 42-46. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6936
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Clinical research
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