FEATURES OF PROTEIN STRUCTURE AND THE IMMUNOGENICITY OF ACTUAL INFLUENZA VACCINES
Keywords:
vaccines against a virus of influenza, immunogenicity, albuminous composition
Abstract
Immunogenicity and the basic characteristics of albuminous components of new vaccines against a virus of influenza A (H1N1) by Panenza and MonoGrippol were investigated. The quantitative and qualitative structure of proteins of both vaccines is revealed: five – the split vaccine of Panenza, two – subisolated vaccines of MonoGrippol. It was established that the immunogenicity of investigated subisolated adjuvant vaccine twice exceeds an immunogenicity of viral-split nonadjuvant vaccine.Downloads
Download data is not yet available.
References
1. Лавров В. Ф. Основы иммунологии, эпидемиологии и профилактики инфекционных болезней / В. Ф. Лавров, Е. В. Русакова, А. А. Шапошников [и др.] – М. : ЗАО «МП Гигиена», 2007. – 311 с.
2. Chaloupka I. Comparative analisis of six European influenza vaccines / I. Chaloupka, A. Schuler, M. Marschall, H. Meier-Ewert // Eur. J. Clin. Microbiol. Infect. Dis. – 1996. – V. 15. – P. 121–127.
3. Бектимиров Т. А. Методы определения показателей качества иммунобиологических препаратов для профилактики и диагностики гриппа : Методические указания / Т. А. Бектимиров, Н. И. Лонская, Н. А. Агафонова [и др.] – М. : Федеральный центр Госсанэпиднадзора Минздрава России, 2003. – 32 с.
4. Xie H. Evaluating the vaccine potential of an influenza A viral hemagglutinin and matrix double insertion DNA plasmid / H. Xie, T. Liu, H. Chen [et al.] // Vaccine. – 2007. – V. 25, № 44. – P. 7649–7655.
5. Караулов А. В. Инфекции и иммунодефициты – приоритеты сегодня / А. В. Караулов // Практикующий врач. – 1997. – № 9. – С. 3–4.
6. Kunzel W. Kinetics of humoral antibody response to trivalent inactivated split influenza vaccine in subjects previously vaccinated or vaccinated for the first time / W. Kunzel, H.Glathe, H. Engelman, Ch. Van Hoecke // Vaccine. – 1996. – V. 14, № 12. – P. 1108–1110.
7. Laddy D. J. Immunogenicity of novel consensus-based DNA vaccines against avian influenza / D. J. Laddy, J. Yan, N. Corbitt [et al.] // Vaccine. – 2007. – V. 25, № 16. – P. 2984–2989.
8. Grebe K. M. Heterosubtypic immunity to influenza A virus: where do we stand? / K. M. Grebe, J. W. Yewdell, J. R. Bennink // Microbes and Infection. – 2008. – V. 10, № 9. – P. 1024–1029.
9. Ochiai H. Inactivated influenza vaccine effectiveness against influenza-like illness among young children in Japan – With special reference to minimizing outcome misclassification / H. Ochiai, M. Fujieda, S. Ohfuji [et al.] // Vaccine. – 2009. – V. 27, № 50. – P. 7031–7035.
10. Beran J. Evaluation of reactogenicity and immunogenicity of two influenza vaccines (vaxigrip and fluarix) in the season 1996–1997 / J. Beran, R. Prymula, R. Chilber [et al.] // Cent. Eur. J. Public Health. – 1998. – № 64. – P. 269–273.
2. Chaloupka I. Comparative analisis of six European influenza vaccines / I. Chaloupka, A. Schuler, M. Marschall, H. Meier-Ewert // Eur. J. Clin. Microbiol. Infect. Dis. – 1996. – V. 15. – P. 121–127.
3. Бектимиров Т. А. Методы определения показателей качества иммунобиологических препаратов для профилактики и диагностики гриппа : Методические указания / Т. А. Бектимиров, Н. И. Лонская, Н. А. Агафонова [и др.] – М. : Федеральный центр Госсанэпиднадзора Минздрава России, 2003. – 32 с.
4. Xie H. Evaluating the vaccine potential of an influenza A viral hemagglutinin and matrix double insertion DNA plasmid / H. Xie, T. Liu, H. Chen [et al.] // Vaccine. – 2007. – V. 25, № 44. – P. 7649–7655.
5. Караулов А. В. Инфекции и иммунодефициты – приоритеты сегодня / А. В. Караулов // Практикующий врач. – 1997. – № 9. – С. 3–4.
6. Kunzel W. Kinetics of humoral antibody response to trivalent inactivated split influenza vaccine in subjects previously vaccinated or vaccinated for the first time / W. Kunzel, H.Glathe, H. Engelman, Ch. Van Hoecke // Vaccine. – 1996. – V. 14, № 12. – P. 1108–1110.
7. Laddy D. J. Immunogenicity of novel consensus-based DNA vaccines against avian influenza / D. J. Laddy, J. Yan, N. Corbitt [et al.] // Vaccine. – 2007. – V. 25, № 16. – P. 2984–2989.
8. Grebe K. M. Heterosubtypic immunity to influenza A virus: where do we stand? / K. M. Grebe, J. W. Yewdell, J. R. Bennink // Microbes and Infection. – 2008. – V. 10, № 9. – P. 1024–1029.
9. Ochiai H. Inactivated influenza vaccine effectiveness against influenza-like illness among young children in Japan – With special reference to minimizing outcome misclassification / H. Ochiai, M. Fujieda, S. Ohfuji [et al.] // Vaccine. – 2009. – V. 27, № 50. – P. 7031–7035.
10. Beran J. Evaluation of reactogenicity and immunogenicity of two influenza vaccines (vaxigrip and fluarix) in the season 1996–1997 / J. Beran, R. Prymula, R. Chilber [et al.] // Cent. Eur. J. Public Health. – 1998. – № 64. – P. 269–273.
How to Cite
Volyanskiy, A. Y., Romanova, E. A., Sydorenko, T. A., Igumnova, N. I., Yuchimenko, V. I., Kashpur, N. V., & Martynov, A. V. (1). FEATURES OF PROTEIN STRUCTURE AND THE IMMUNOGENICITY OF ACTUAL INFLUENZA VACCINES. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (21), 5-9. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6886
Issue
Section
Fundamental research
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
