VALIDATION OF THE EXPERIMENTAL MODEL FOR INTERBODY BONE FUSION IN RATS
Keywords:
experimental modeling, interbody fusion, instrumented spinal fusion
Abstract
Purpose of this study is to develop and to assess surgical tactic of the instrumented interbody fusion modeling. 18 rats were selected and divided into two groups. In the first group anterior interbody fusion of the lumbar spine was performed and in the second group tail was instrumented. Experimental modeling of the lumbar spine results in death in all operated animals. Instrumented interbody fusion of the tail provides stable fixation during 4 weeks after surgery.Downloads
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References
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2. Kawakami N. Animal models of scoliosis / N. Kawakami, M. Deguchi, T. Kanemura // Animals models in orthopaedic research, Chapter 5. — 1999. — Vol. 30. — P. 549—564.
3. Muschik M. Experimental anterior spine fusion using bovine bone morphogenetic protein : a study in rabbits / [M. Muschik, D. Schlenzka, V. Ritsilä, C. Tennstedt] // J Orthop Sci. — 2000. — Vol. 5 (2). —P. 165—70.
4. Haisheng L. Recombinant Human Bone Morphogenetic Protein-2 Enhances Anterior Spinal Fusion in a Thoracoscopically Instrumented Animal Model / [L. Haisheng, Z. Xuenong, C. Woo, D. Ming] // Spine. — 2005. — Vol. 30. — Iss. 8. — P. 890—896.
5. Sucato D. Recombinant Human Bone Morphogenetic Protein-2 Enhances Anterior Spinal Fusion in a Thoracoscopically Instrumented Animal Model / [D. Sucato, D. Hedequist, H. Zhang, W. A. Pierce] // JBJS. — 2009. — Vol. 34. — Iss. 15. — P. E501—E506.
6. Sidhu K. S. Anterior cervical interbody fusion with rhBMP-2 and tantalum in a goat model / K. S. Sidhu, T. D. Prochnow, P. Schmitt, J. Fischgrund, S. Weisbrode, H. N.Herkowitz // Spine. — 2001. — № l (5). — P. 331—340.
7. Pekmezci M. The Effect of Anterior Spinal Fusion on Spinal Canal Development in an Immature Porcine Model / M. Pekmezci, G. Yilmaz, K. Daglioglu, M. Gulsen, A. Alanay // Spine. — 2009. — Vol. 34. — Iss. 15. — P. E501—E506.
8. Elliott D. M. Young investigator award winner : validation of the mouse and rat disc as mechanical models of the human lumbar disc / D. M. Elliott, J. J. Sarver // Spine. — 2004. — Vol. 29. — P. 713—722.
9. Espinoza Orías A. A. Rat disc torsional mechanics : effect of lumbar and caudal levels and axial compression load / A. A. Espinoza Orías, D. M. Elliott // Spine. —2009. — Vol. 3. — P. 204—209.
10. Європейська конвенція про захист хребетних тварин, що використовуються для дослідних та інших наукових цілей. Страсбург, 18 березня 1986 року : офіційний переклад [Електронний ресурс] / Верховна Рада України. — (Міжнародний документ Ради Європи). — Режим доступу до ресурсу : http://zakon.rada.gov.ua/cgi-bin/laws/main.cgi?nreg=994_137.
How to Cite
Petrenko, D. E., Ivanov, G. V., & Mezentsev, A. A. (1). VALIDATION OF THE EXPERIMENTAL MODEL FOR INTERBODY BONE FUSION IN RATS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (23), 5-9. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6720
Issue
Section
Fundamental research
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