CLINICAL AND INSTRUMENTAL CHARACTERISTICS OF JUVENILE CHRONIC ARTHRITIS EVOLUTION

  • I. S. Lebets SI «Institute of children and adolescents health care of the NAMSU», Kharkiv, Ukraine
  • E. M. Zaytseva SI «Institute of children and adolescents health care of the NAMSU», Kharkiv, Ukraine
  • G. V. Letyago V.N. Karazin Kharkiv National University, Kharkiv, Ukraine https://orcid.org/0000-0002-6327-1321
Keywords: juvenile chronic arthritis, juvenile idiopathic arthritis, children

Abstract

The purpose of the study was to investigate the clinical symptoms and evolution of juvenile chronic arthritis (JCA) at different stages of it development. 39 children with duration of JCA from 6 months to 5 years in age from 2 to 18 years were examined. All patients underwent clinical examination, indicators of acute phase of inflammation (CRP, sialic acid, seromucoid, glycoproteins), rheumatoid factor, circulating immune complexes, complement, instrumental methods (X-ray and ultrasound, capillaroscopy of nail bed) were evaluated. Activity of the disease was estimated by disease activity score (DAS28). Statistically was determined the relative value (P). It was found that the disease started with monoarthritis (63,37 %). In the future, in half of the patients was formed oligoarthritis with damaging of large and medium-sized joints (68,25 %). In the majority of surveyed disease occurred against the backdrop of the minimal activity of the inflammatory process. On the stages of evolution recurrence of arthritis were observed in one third of children. If duration of the sickness is more than 5 years, it has become less frequent, than in previous years. The absence of clinical and radiographic manifestations of JCA after the abolition of medical treatment within one year, became the basis for the assumption that the disease remission, which was on the third year of the disease 25,93 %, on the fourth – 33,33 %, on the fifth – 36,36 %. The absence of radiographic signs of bone destruction, disability of patients allows interpreting JCA as a positive option of chronic juvenile idiopathic arthritis.

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Author Biographies

I. S. Lebets, SI «Institute of children and adolescents health care of the NAMSU», Kharkiv, Ukraine

61000, Jubilee ave., 52a, Kharkiv, Kharkiv region

E. M. Zaytseva, SI «Institute of children and adolescents health care of the NAMSU», Kharkiv, Ukraine

61000, Jubilee ave., 52a, Kharkiv, Kharkiv region

G. V. Letyago, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine

Svobody sq., 6, Kharkiv, 61022, Ukraine

 

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Published
2016-11-17
How to Cite
Lebets, I. S., Zaytseva, E. M., & Letyago, G. V. (2016). CLINICAL AND INSTRUMENTAL CHARACTERISTICS OF JUVENILE CHRONIC ARTHRITIS EVOLUTION. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (31), 18-22. Retrieved from https://periodicals.karazin.ua/medicine/article/view/6352
Section
Clinical research