TREATMENT OF ARTERIAL HYPERTENSION AND QTc INTERVAL DURATION THROUGH CLINICAL PRACTICE

Abstract

This clinical case presents the treatment of arterial hypertension (AH) with improvement levels of daily average blood pressure (BP) in comparison with the initial level at the background of increasing the proportion of elongated corrected interval QTc and a violation of the average daily profile. The patient K. receiving ramipril in the morning 5 mg and 10 mg evening after 3 months during the control of daily monitoring of BP and ECG there is a decrease of average daily SBP and DBP daily average. Normalization of the average daily profile of DBP from «excessive degree of nocturnal BP reduction «in the» normal degree of nocturnal BP reduction». At the same time, however, there is an increase in the number of episodes of lengthening the interval corrected QTc and increase the proportion of elongated corrected interval QTc as well as the conversion of the average daily profile SBP «excessive degree of nocturnal BP reduction» in the «insufficient degree of nocturnal BP reduction», which increases the risk of acute cardiovascular events and requires further adjustment of therapy. This case demonstrates the individual patient's response to antihypertensive therapy in view of increased psycho-emotional stress associated with the specifics of her work.