DEPRESSIVE DISORDERS MANAGEMENT IN ISCHEMIC HEART DISEASE PATIENTS
Abstract
OBJECTIVE: To study the dynamics of clinical, instrumental and psychological parameters in patients with ischemic heart disease (IHD) and comorbid depressive disorders on the stages of standard baseline therapy and additional tianeptine intake to develop proposals to improve management of such patients.METHODS: 142 patients (77 males and 65 females) with the painful form of IHD in age from 45 to 60 years were examined. Quality of life (QoL), levels of depression, anxiety, pain perception; functional classes (FC) of stable angina pectoris and HRV indices were studied in patients with IHD in groups with a presence and absence of the depressive disorders at the beginning, in 3 weeks, 3, 6 and 12 months of baseline therapy and before and after 4 weeks of tianeptine adding to baseline therapy.
RESULTS: It was determined, that the depressive disorders result in worsening of QoL and HRV indexes. It was shown, that basic IHD therapy in the group of depressed patients with positive dynamics doesn’t allow to achieve QoL and HRV indexes registered in the group of non-depressed patients. Also adding of tianeptine to baseline IHD therapy in depressed patients allows not only to improve QoL and HRV indexes, but also to attain the values of the proper indexes as in non-depressed group.
CONCLUSIONS: Patients with IHD should be examined for the presence of depressive disorders. In pa-tients with IHD and clinically significant depression diagnosed antidepressant tianeptine must be added to baseline therapy.
Downloads
Download data is not yet available.
Published
2015-07-05
How to Cite
Kulik, A. L., & Rank, I. A. (2015). DEPRESSIVE DISORDERS MANAGEMENT IN ISCHEMIC HEART DISEASE PATIENTS. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (25), 22-28. Retrieved from https://periodicals.karazin.ua/medicine/article/view/3396
Issue
Section
Clinical research
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.