Epidemiology of knee osteoarthritis
Abstract
Introduction. Osteoarthritis of the knee joint is a progressive incurable disease, which in the case of a severe course at a late stage leads to total joint replacement. Recently, experts have focused their attention to the prevention and treatment of early osteoarthritis, so it is important to understand the prevalence, frequency, and modified risk factors for knee OA. The aim is to investigate the patterns of morbidity and prevalence of osteoarthritis of the knee joint on the basis of scientific analysis of relevant modern literature. Materials and methods. Research material – scientific articles in the MEDLINE database for the period 2016–2020, reflecting the epidemiological indicators of osteoarthritis of the knee joint, and additional search for articles from bibliographic lists of selected literature sources. Research methods – a systematic review of relevant sources of literature. Results. Osteoarthritis of the knee joint is one of the most common diseases of the musculoskeletal system. The frequency of osteoarthritis steadily increases with age, overweight. The progressive nature of the disease, the presence of persistent pain lead to limited functionality and reduced efficiency; such patients in some cases require surgical treatment aimed at replacing the compromised joint, which requires significant economic costs, medical rehabilitation and social readaptation of patients and is a heavy burden for both the patient and society as a whole. The lack of correlation between clinical symptoms and radiological signs of osteoarthritis of the knee joint leads to low availability of orthopedic care: more than 30 % of patients with a first diagnosis have a pronounced stage of the disease, and in some cases the pathology is diagnosed only in connection with complications; the diagnosis of osteoarthritis due to the high percentage of painless development of the disease (40 %) is often established in the terminal stages. All this indicates the need for further research on various factors influencing the frequency, prevalence, economic and social burden of osteoarthritis of the knee. Conclusions. Osteoarthritis of the knee joint is characterized by high incidence, which increases with age, progressive course, limited functional capabilities. Treatment of such patients requires significant economic costs of society. A significant increase in the prevalence of osteoarthritis of the knee is associated with increased life expectancy, obesity and some other factors that require further research.
Downloads
References
The US Burden of Disease Collaborators. The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States. JAMA. 2018; 319 (14): 1444–1472. Doi: https://doi.org/10.1001/jama.2018.0158
Glyn-Jones S, Palmer AJ, Agricola R, et al. Osteoarthritis. Lancet 2015; 386 (9991): 376–87. Doi: https://doi.org/10.1016/ S2666-7568(21)00172-0
Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019; 393 (10182): 1745–1759. Doi: https://doi.org/10.1016/S0140-6736(19)30417-9
Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012; 380 (9859): 2163–96. Doi: https://doi.org/10.1016/S0140-6736(12)61729-2
Karateev AE, Lyla AM. Osteoartryt: sovremennaia klynycheskaia kontseptsyia y nekotorye perspektyvnыe terapevtycheskye podkhody. [Osteoarthritis: a modern clinical concept and some promising therapeutic approaches] Nauchno-praktycheskaia revmatolohyia. 2018; 56 (1): 70–81. Doi: https://doi.org/10.14412/1995-4484-2018-70-81 [Russian]
Hunter TM, Boytsov NN, Zhang X, Schroeder KM. Prevalence of rheumatoid arthritis in the United States adult population in healthcare claims databases, 2004–2014. Rheumatol Int 2017; 37: 1551. Doi: https://doi.org/10.1007/s00296-017-3726-1
Chen D, Shen J, Zhao W, Wang T, Han L, Hamilton JL, Im H-J. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Research (2017) 5, 16044; Doi: https://doi.org/10.1038/boneres.2016.44
Bannuru RR, Osani MC, Vaysbrot EE, Arden NK, Bennell K, Bierma-Zeinstra SMA et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019; 27 (11): 1578–89. Doi: https://doi.org/10.1016/j.joca.2019.06.011
Felson DT. Osteoarthritis as a disease of mechanics. Osteoarthritis Cartilage. 2013; 21: 10–15. Doi: https://doi.org/10.1016/j.joca.2012.09.012
Robinson WH, et al. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016; 12: 580–592. Doi: https://doi.org/10.1038/nrrheum.2016.136
Li D, Li S, Chen Q, Xie X. The Prevalence of Symptomatic Knee Osteoarthritis in Relation to Age, Sex, Area, Region, and Body Mass Index in China: A Systematic Review and Meta-Analysis. Front. Med., 16 July 2020. Doi: https://doi.org/10.3389/fmed.2020.00304
Bijlsma JWJ, Berenbaum F, Lafeber FPJG. Osteoarthritis: An update with relevance for clinical practice. Lancet 2011; 377: 2115–2126. Doi: https://doi.org/10.1016/S0140-6736(11)60243-2
Kelli D. Allen, Yvonne M. Golightl. Epidemiology of osteoarthritis: state of the evidence. Curr Opin Rheumatol 2015, 27: 000–000. Doi: https://doi.org/10.1097/BOR.0000000000000161
Runhaar J, Zhang Y. Can we prevent OA? Epidemiology and public health insights and implications. Rheumatology. 2018;57:iv3iv9 Doi: https://doi.org/10.1093/rheumatology/key014
Loeser RF, Collins JA, Diekman BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol 12: 412–420. Doi: https://doi.org/10.1038/nrrheum.2016.65
Wluka AE, Lombard CB, Cicuttini FM Tackling obesity in knee osteoarthritis. Nat Rev Rheumatol. 2013; 9: 225–235. Doi: https://doi.org/10.1038/nrrheum.2012.224
Bliddal H, Leeds AR, Christensen R. Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons – a scoping review. Obes Rev. 2014 Jul;15 (7): 578–586. Doi: https://doi.org/10.1111/obr.12173
Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Marlene Franse M, Bridgett L et al. The global burden of hip and knee osteoarthritis: Estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis 2014; 73: 1323–1330. Doi http://dx.doi.org/10.1136/annrheumdis-2013-204763
Murray DW, Liddle AD, Judge A, Pandit H. Bias and unicompartmental knee arthroplasty. Bone Joint J, 2017. 99-b (1): p. 12–15. Doi: http://dx.doi.org/10.1302/0301-620X.99B1.BJJ-2016-0515.R1
Ng Man Sun S, Gillott E, Bhamra J, Briggs T. Implant use for primary hip and knee arthroplasty: are we getting it right first time? J Arthroplast. 2013; 28(6): 908–12. Doi: http://dx.doi.org/10.1016/j.arth.2012.11.012
Loth FL, Liebensteiner MC, Giesinger JM, Giesinger K, Bliem HR, Holzner B.. What makes patients aware of their artificial knee joint? BMC Musculoskelet Disord. 2018;19(1):5. Doi: https://doi.org/10.1186/s12891-017-1923-4
Liddle AD, Judge A, Pandit H, Murray DW. Adverse outcomes after total and unicompartmental knee replacement in 101,330 matched patients: a study of data from the National Joint Registry for England and Wales. Lancet. 2014 Oct 18;384(9952):1437-45. Doi: https://doi.org/10.1016/S0140-6736(14)60419-0
Ditton E, Johnson S, Hodyl N, Flynn T, Pollack M, Ribbons K, Walker FR, Nilsson M. Improving Patient Outcomes Following Total Knee Arthroplasty: Identifying Rehabilitation Pathways Based on Modifiable Psychological Risk and Resilience Factors. Front. Psychol. 2020:8p Doi: https://doi.org/10.3389/FPSYG.2020.01061
Kulshrestha V, Kulshrestha V, Datta B, Kumar S, Mittal G. Outcome of Unicondylar knee arthroplasty vs Total knee arthroplasty for early medial compartment arthritis: a randomized study. J Arthroplast. 2017; 32 (5): 1460–9. Doi: https://doi.org/10.1016/j.arth.2016.12.014
Roos EM, Arden NK. Strategies for the prevention of knee osteoarthritis. Nature reviews Rheumatology. 2016; 12 (2): 92–101. Doi: https://doi.org/10.1038/nrrheum.2015.135
Bortkevych OP, Harmash OO, Kalashnikov OV, Kovalenko VM, Poluliakh MM, Protsenko HO ta in. Osteoartroz. Klinichna nastanova. [Osteoarthritis. Clinical guidelines] Kyiv; 2017. 481 s. [Elektronnyi resurs]. – Rezhym dostupu: https://www.dec.gov.ua/wp-content/uploads/2019/11/akn_osteo.pdf [Ukrainian]
Kelli D. Allen, Yvonne M. Golightl. Epidemiology of osteoarthritis: state of the evidence. Curr Opin Rheumatol. 2016, 27: 000–000. Doi: https://doi.org/10.1097/BOR.0000000000000161
Cervini C, Margolongo R. J’artrosi terminologia. Realizzazioni scientifiche. 1996;2:15–19.
Sebbag E, Felten R, Sagez F, Sibilia J, Devilliers H, Arnaud L. The world-wide burden of musculoskeletal diseases: a systematic analysis of the World Health Organization Burden of Diseases Database. Ann Rheum Dis. 2019; 78 (6): 844–8. Doi: http://dx.doi.org/10.1136/annrheumdis-2019-215142
Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine. 2020; 2930: 100587. Doi: https://doi.org/10.1016/j.eclinm.2020.100587
United States Bone and Joint Initiative. The Burden of Musculoskeletal Diseases in the United States (BMUS). In: In. Fourth ed. Rosemont, IL. 2018: Available at https://www.boneandjointburden.org/fourth-edition. Accessed June 12, 2019.
Wallacea IJ, Worthington S, Felsonc DT, Jurmaind RD, Wrene KT, Maijanenf H, Woodsg RJ, Liebermana DE. Knee osteoarthritis has doubled in prevalence since the mid-20th century. PNAS. 2017; 114 (35): 9332–9336. www.pnas.org/lookup/suppl/doi:10. 1073/pnas.1703856114/-/DCSupplementa
Hannan MT, Anderson JJ, Pincus T, Felson DT. Educational attainment and osteoarthritis: differential associations with radiographic changes and symptom reporting. J Clin Epidemiol. 1992; 45 (2): 139–47. Doi: https://doi.org/10.1016/0895-4356(92)90006-9
Callahan LF, Shreffler J, Siaton BC, et al. Limited educational attainment and radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis using data from the Johnston County (North Carolina) Osteoarthritis Project. Arthritis Res Ther 2010;12(2):R46. Doi: https://doi.org/10.1186/ar2956
Internet-resurs Derzhavnoi sluzhby statystyky Ukrainy [Internet resource of the State Statistics Service of Ukraine] [Elektronnyi resurs]. – Rezhym dostupu: http://database. ukrcensus.gov.ua/MULT/Dialog/statfile_c.asp. [Ukrainian]
Centers for Disease Control and Prevention. 2003 National Health Interview Survey; 2030 Census projected population. Available at https://www.cdc.gov/ arthritis/data_statistics/national-statistics.html. Accessed January 19, 2019.
Barbour KE, Helmick CG, Boring M, Brady TJ. Vital Signs: Prevalence of Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation – United States, 2013–2015. MMWR Morb Mortal Wkly Rep. 2017; 66 (9): 246–253. Doi: https://doi.org/10.15585/mmwr.mm6609e
Menon J. Osteoarthritis related absenteeism and activity limitations. Osteoarthritis and Cartilage. 2015; 23: A343.
Disease GBD, Injury I, Prevalence C. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392 (10159): 1789–858.
Kloppenburg M, Berenbaum F. Osteoarthritis year in review 2019: Epidemiology and therapy. Osteoarthritis and Cartilage 2020; 28: 242–248. Doi: https://doi.org/10.1016/j.joca.2020.01.002
Chua JR, Jamal S, Riad M, Castrejon I, Malfait AM, Block JA, et al. Disease burden in osteoarthritis is similar to that of rheumatoid arthritis at initial rheumatology visit and significantly greater six months later. Arthritis Rheum 2019; 71 (8): 1276–84. Doi: https://doi.org/10.1002/art.40869
Safiri S, Kolahi AA, Smith E, et al. Global, regional and national burden of osteoarthritis 1990–2017: a systematic analysis of the global burden of disease study 2017. Ann Rheum Dis 2020. Doi: https://doi.org/10.1136/annrheumdis-2019-216515
Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med 2010; 26 (3): 355–69. Doi: https://doi.org/10.1016/j.cger.2010.03.001
Felson DT, Lawrence RC, Dieppe PA, et al. Osteoarthritis: new insights.Part1: the disease and its risk factors. Ann Intern Med 2000; 133 (8): 635–46. Doi: https://doi.org/10.7326/0003-4819-133-8-200010170-00016
Arthritis Foundation. Arthritis by the Numbers. In: Atlanta, GA: Arthritis Foundation; 2019: https://www.arthritis.org/Documents/Sections/About- Arthritis/arthritis-facts-stats-figures.pdf. Accessed April 5, 2019
Swain S, Sarmanova A, Mallen C, et al. Trends in incidence and prevalence of osteoarthritis in the United Kingdom: findings from the Clinical Practice Research Datalink (CPRD). Osteoarthritis Cartilage 2020. Doi: https://doi.org/10.1016/j.joca.2020.03.004
Vina ER, Kwoh CK. Epidemiology of osteoarthritis: literature update. Curr Opin Rheumatol 2018; 30 (2): 160–7. Doi: https://doi.org/10.1097/BOR.0000000000000479
Osteoarthritis Research Society International. Osteoarthritis: A Serious Disease, submitted to the U.S. Food andDrug Administration. 2016. https:// www.oarsi.org/sites/default/files/docs/2016/oarsi_white_paper_oa_serious_disease_121416_1.pdf. Accessed March 27, 2019
Barbour KE, Boring M, Helmick CG, Murphy LB, Qin J. Prevalence of Severe Joint Pain Among Adults with Doctor-Diagnosed Arthritis—United States, 2002–2014. MMWR Morb Mortal Wkly Rep. 2016; 65 (39): 1052–1056. Doi: https://doi.org/10.15585/mmwr.mm6539a2
Finney A, Dziedzic KS, Lewis M, Healey E. Multisite peripheral joint pain: a cross-sectional study of prevalence and impact on general health, quality of life, pain intensity and consultation behaviour. BMC Musculoskeletal Disorders. 2017; 18: 535. Doi: https://doi.org/10.1186/s12891-017-1896-3
Tossini NB, Zacharias ALS, Abrantes LSS, da Silva Serrao PRM. Initial stages of hand osteoarthritis do not affect the extrinsic muscles of the hand: a cross‑sectional study. Scientifc Reports 2021; 11: 5381. Doi: https://doi.org/10.1038/s41598-021-85054-3
Chou L, Ellis L, Papandony M, Seneviwickrama KLMD, Cicuttini FM, Sullivan K, et al. Patients’ perceived needs of osteoarthritis health information: A systematic scoping review. PLoS ONE 2018; 13 (4): e0195489. Doi: https://doi.org/10.1371/journal.pone.0195489
Hootman JM, Helmick CG, Barbour KE, Theis KA, Boring MA. Updated Projected Prevalence of Self-Reported Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation Among US Adults, 2015–2040. Arthritis Rheumatol. 2016; 68 (7): 1582–1587.
Doi: https://doi.org/10.15585/mmwr.mm6539a2
Pereira D, Peleteiro B, Araujo J, Branco J, Santos RA, Ramos E. The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthritis Cartilage 2011;19(11):1270–85. Doi: https://doi.org/10.1016/j.joca.2011.08.009
Litwic A, Edwards MH, Dennison EM, Cooper C. Epidemiology and burden of osteoarthritis. Br Med Bull 2013; 105: 185–99. Doi: https://doi.org/10.1093/bmb/lds038
Wang X, Oo WM, Linklater JM. How well do radiographic, clinical and self-reported diagnoses of knee osteoarthritis agree? Findings from the Hertfordshire cohort study. Rheumatology 2018; 57: iv51iv60 Doi: https://doi.org/10.1093/rheumatology/kex501
Hawker GA, Gignac MA, Badley E, et al. A longitudinal study to explain the pain-depression link in older adults with osteoarthritis. Arthritis Care Res (Hoboken). 2011; 63 (10): 1382–1390. Doi: https://doi.org/10.1002/acr.20298
Smith TO, Dainty JR, MacGregor A. Trajectory of social isolation following hip fracture: an analysis of the English Longitudinal Study of Ageing (ELSA) cohort. Age Ageing. 2018; 47 (1): 107–112. Doi: https://doi.org/10.1093/ageing/afx129
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.