ENDOGENOUS RETROVIRUSES AS GENETIC MODULES THAT SHAPE THE GENOME REGULATORY NETWORKS DURING EVOLUTION

  • M. M. Popov V.N. Karazin Kharkiv National University, Kharkiv, Ukraine https://orcid.org/0000-0002-5759-9654
  • T. Yu Kolotova SI «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine
  • M. B. Davidenko SI «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine
Keywords: endogenous retroviruses, enhancer, promoter, lncRNA, regulatory networks, R-operon, mobile elements, genome evolution

Abstract

Endogenous retroviruses (ERV) are the descendants of exogenous retroviruses that integrated into the germ cells genome, fixed and became inheritable. ERVs have evolved transcriptional enhancers and promoters that allow their replication in a wide range of tissue. Because ERVs comprise the regulatory elements it could be assume that ERVs capable to shape and reshape genomic regulatory networks by inserting their promoters and enhancers in new genomic loci upon retrotransposition. Thus retroransposition events can build new regulatory regions and lead to a new pattern of gene activation in the cell. In this review we summarize evidence which revealed that ERVs provide a plethora of novel gene regulatory elements, including tissue specific promoters and enhancers for protein-coding genes or long noncoding RNAs in a wide range of cell types. The accumulated findings support the hypothesis that the ERVs have rewired the gene regulatory networks and act as a major source of genomic regulatory innovation during evolution.

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Author Biographies

M. M. Popov, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine

61022, Kharkiv, 4 Nauky Avenue

 
T. Yu Kolotova, SI «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine

14-16, Pushkinskaya St. 
Kharkov,Ukraine
61057/Zip

M. B. Davidenko, SI «Mechnikov Institute of Microbiology and Immunology of National Academy of Medical Sciences of Ukraine», Kharkiv, Ukraine

14-16, Pushkinskaya St. 
Kharkov,Ukraine
61057/Zip

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Published
2019-01-09
How to Cite
Popov, M., Kolotova, T., & Davidenko, M. (2019). ENDOGENOUS RETROVIRUSES AS GENETIC MODULES THAT SHAPE THE GENOME REGULATORY NETWORKS DURING EVOLUTION. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (36), 80-95. Retrieved from https://periodicals.karazin.ua/medicine/article/view/12194
Section
Reviews