DEVELOPMENT AND PROGRESSION OF OBESITY IN PATIENTS WITH CORONARY HEART DISEASE: EMPHASIS ON LEPTIN GENE POLYMORPHISM (Arg223Gln)
Abstract
The article assesses the contribution of leptin gene polymorphism (Arg223Gln) in the development and progression of obesity in patients with coronary heart disease. 222 patients with coronary heart disease and obesity were surveyed. The study of leptin gene polymorphic locus Arg223Gln was performed by polymerase chain reaction of all examined patients. G allele and G/G genotype of the leptin gene polymorphism (Arg223Gln) are more common among the patients with coronary heart disease and obesity and the frequency of their detection increases with the growth of the degree of obesity.
G allele and G/G genotype of leptin gene polymorphism (Arg223Gln) were associated with the development of obesity in CHD patients, and the frequency of their detection increases with the growth of BMI in the Ukrainian population.Given the urgency of the comorbid pathology problem further research should be directed towards the study of other associations of gene polymorphisms with the development and progression of cardiovascular diseases and obesity.
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