DEVELOPMENT AND PROGRESSION OF OBESITY IN PATIENTS WITH CORONARY HEART DISEASE: EMPHASIS ON LEPTIN GENE POLYMORPHISM (Arg223Gln)
The article assesses the contribution of leptin gene polymorphism (Arg223Gln) in the development and progression of obesity in patients with coronary heart disease. 222 patients with coronary heart disease and obesity were surveyed. The study of leptin gene polymorphic locus Arg223Gln was performed by polymerase chain reaction of all examined patients. G allele and G/G genotype of the leptin gene polymorphism (Arg223Gln) are more common among the patients with coronary heart disease and obesity and the frequency of their detection increases with the growth of the degree of obesity.
Bolouri A., Paghalea R. S., Mahani M. K., Karajibani M. // Arq Bras Cardiol. – 2016. – Oct; 107 (4). –
2. Leptin receptor gene polymorphisms and morbid obesity in Mexican patients / M.E. Rojano-Rodriguez, J.L. Beristain-Hernandez, B. Zavaleta-Villa, et al. // Hereditas. – 2016. – Feb 22; 153. – Р: 2.
3. Genetics of obesity: can an old dog teach us new tricks? // G. S.Yeo // Diabetologia. – 2016. – Dec 24. doi: 10.1007/s00125-016–4187-x.
4. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil /
V. S. Mattevi, V. M. Zembrzuski // Hutz Int J Obes Relat Metab Disord. – 2002. – Vol. 26(9). – P. 1179–1185.
5. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case control study in Spain / O. Portolés, J.V. Sorlí, F. Francés, et al. // Eur J Epidemiol. – 2006. – Vol. 21 (8). – P. 605–612.
6. Yako Y. Y. Molecular investigation of genetic and environmental factors contributing to obesity in adolescent learners residing in the semi-urban/rural areas of the Western Cape Province, South Africa: Dissertation presented for the degree of Doctor of Philosophy. – Stellenbosch. – 2012.
7. Leptin receptor gene variation and obesity: lack of association in a white British male population /
T. Gotoda, B. S. Manning, A. P. Goldstone, et al. // Hum Mol Genet. – 1997. – Vol. 6 (6). – P. 869–876.
8. Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects / A. Constantin, G. Costache, Sima A. V. et al. // Biochem Biophys Res Commun. – 2010. – Vol. 391(1). – P. 282–286.
9. A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference / M. Heo, R. L. Leibel, K. R. Fontaine, et al. // Int J Obes Relat Metab Disord. – 2002. – Vol. 26(5). – P. 640–646.
10. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability / N. Yiannakouris, M. Yannakoulia, L. Melistas, et al. // J Clin Endocrinol Metab. – 2001. – Vol. 86(9). – P. 4434–4439.
Copyright (c) 2017 The Journal of V. N. Karazin Kharkiv National University, series "Medicine"
This work is licensed under a Creative Commons Attribution 4.0 International License.
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.