Ethylation of 5-acetyl-5-methyl-7-phenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine
DOI:
https://doi.org/10.26565/2220-637X-2013-22-04Keywords:
4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, alkylation, 3-amino-1,2,4-triazole, nuclear Overhauser effectAbstract
Alkylation of 5‑acetyl-5-methyl-7-phenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine with ethyl bromide in heterogeneous system КОН–H2O–MeCN leads to the formation of the mixture of two isomers. The structures of the latter were elucidated by NOE experiment. Recrystallization of the obtained mixture from EtOAc results in the major product of alkylation, 5‑acetyl-4-ethyl-5-methyl-7-phenyl-4,7-dihydro[1,2,4]triazolo[1,5‑a]pyrimidine.
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