New electrochemical sensors for dopamine determination in drugs

Keywords: electrochemical sensors, silica-organic material, phosphonic groups, dopamine, voltammetry

Abstract

The electrodes based on silica-organic materials with immobilized phosphonic groups and sorbed ions of Cu2+ and Fe3+ were created for dopamine determination. The technique of differential pulse voltametry was used for electrochemical measurements. It was found, that surface complexes of Cu2+ or Fe3+ and phosphonic groups have electrocatalytic effect on dopamine oxidation.

The procedures for dopamine content determination in medicine using the obtained sensors were developed. The analytical range is 0.005 ‑ 1.38 mmol L−1 (for electrode with Cu2+ ions) and 0.006 ‑ 0.65 mmol L−1 (for electrode with Fe3+ ions), sensitivity – 9.1 and 19.2 mA L mol-1, correspondingly, and limit of detection ‑ 0.002 mmol L−1. Electrochemical sensors show high selectivity and stability.

The procedures tested on commercial pharmaceutical facilities. The measurement trueness was confirmed by independent methods.

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Published
2017-12-27
Cited
How to Cite
Tkachenko, A. B., Veryutina, D. M., Kuzmina, A. I., Chuiko, Y. I., Onizhuk, M. O., Tkachenko, O. S., Sukhov, R. V., Kolosov, M. A., & Panteleimonov, A. V. (2017). New electrochemical sensors for dopamine determination in drugs. Kharkiv University Bulletin. Chemical Series, (29), 75-82. https://doi.org/10.26565/2220-637X-2017-29-08