2-Phenyl-phenantr[9,10]oxazole and 2-(2’-ОН-phenyl)-5–phenyl-1,3,4–oxadiazole as fluorescent probes to study the changes in platelet membranes accompanied the atherosclerosis
Abstract
The search of fluorescent probes to detect pathological changes in platelet membranes caused by the atherosclerosis has been performed. It has been found that the fluorescent probes, which are commonly used for monitoring the cholesterol content in lipoproteins (1,4-ANS, DPH, DMHL) failed to detect the changes in platelet membranes accompanied the atherosclerosis. It has been shown that fluorescence parameters of 2-phenyl-phenantr[9,10]oxazole and 2-(2’-ОН-phenyl)-5–phenyl-1,3,4–oxadiazole are sensitive to the changes in platelet membranes in this case.
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References
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