Study of the quality of pharmaceutical products using potentiometric titrator

doi:10.26565/2220-637X-2013-22-28

Oleg I. Yurchenko V.N. Karazin Kharkiv National University https://orcid.org/0000-0002-7117-4556
Marya A. Hasanova V.N. Karazin Kharkiv National University
Mikhail A. Dobriyan V.N. Karazin Kharkiv National University https://orcid.org/0000-0002-1651-5186
Tetiana V. Chernozhuk V.N. Karazin Kharkiv National University https://orcid.org/0000-0001-5580-7838

DOI: https://doi.org/10.26565/2220-637X-2013-22-28

Keywords: potentiometric titration, autotitration, pharmaceutical products, analysis, validation

Abstract

A practical method of autotitration is presented, that offers the same functions of traditional titration with higher precision. Validation of the new method of the sample's quantity detection in different substances with the use of automatic potentiometric titrator. RSD values were calculated. Good reproductivity of results was shown. The method is proved to be reliable and selective.

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References

Glushhenko N. N. Farmacevticheskaja himija: Uchebnik dlja stud. sred. prof. ucheb. zavedenij / N. N. Glushhenko, T. V. Pleteneva, V. A. Popkov; Pod red. T. V. Pletenevoj. — M.: Izdatel'skij centr "Akademija", 2004. — 384 s.

Farmacevticheskaja himija: Ucheb. posobie / Pod red. L.P.Arzamasceva. – M.: GJeOTAR-MED, 2004. - 640 s.

Farmacevtichnij analіz: Navch. posіb. dlja stud. vishh. farmac. navch. zakl. III—IV rіvnіv akreditacії/P.O. Bezuglij, V. O. Grud'ko, S. G. Leonova ta іn.; Za red. P.O. Bezuglogo,— X.: Vid-vo NFAU; Zolotі storіnki, 2001.— 240 s.

Derzhavna Farmakopeja Ukraїni/rozrobleno Derzhavnim pіdpriєmstvom «naukovo-ekspertnij farmakopejnij centr» na pіdstavі Єvropejs'koї Farmakopeї.–1-she vidannja, Harkіv 2001. – 458s.

Pharmaceutical Chemistry/[NazerA.K.,. MohideenM,. Hameed A.R. S and Patel R.]. - Bulle-tin. 52,2004. - 38-40p.

Differential electrolytic potentiometric titration method for the determination of ciprofloxacin in drug formulations / A.M Abulkibash, S.M Sultan.. A.M Al-Olyan, S.M Al-Ghannam // Ta-lanta. – 2003. – Vol. 61, N. 2. - P. 239-244.

Effect of water content in perchloric acid on the non-aqueous potentiometric titration of nitro-gen-containing compounds /X.S. Qi, R.B. Miller, Y. Namiki, J. Zhang, R.Jacobus //J Pharm Biomed Anal. - 2007. - Vol. 16, N. 3. – P.413.

Christian G.D. Analytical Chemistry/G.D.Christian. - New York:John Wiley & Sons,2004. - 227-233.

Huber W. Titrations in Nonaqueous Solvents/W. Huber //Academic Press. - 1997. - New York and London, 22-27.

Development of Potentiometric Microtitration for Early Chemistry Development/Yong Liu, Ph.D. , Tim Nowak , Jolanta Plewa , Xiaoyi Gong//Talanta. – 2012. – Vol. 7, N. 2. – P. 217.

AND-DV-ER-098 Versija:01 «Levamizola hlorid, poroshok (substancija)».

AND-DV-US Versija:02 « Flukonazol (substancija)».

AND-DV-ER-114 Versija:01 «Levofloksacina gemigidrat».

AND-DV-ER-148 Versija:01 «Propranolola gidrohlorid (substancija)».

AND-DV-ER-010 Versija:04 «Natrija diklofenak, poroshok (substancija)».

AND-DV-ER-062 Versija:02 «Kofeina monogidrat, poroshok (substancija)».

AND-DV-ER-128 Versija:02 «Ambroksola gidrohlorid, poroshok (substancija)».

AND-DV-ER-140 Versija:03 «Artikaina gidrohlorid, poroshok (substancija)».

AND-DV-VR-102 Versija:01 «Fenilin, substancija».

SPC-SR-42 Versija:04 «Glicin»