Ethylation of 5-acetyl-5-methyl-7-phenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine

Keywords: 4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine, alkylation, 3-amino-1,2,4-triazole, nuclear Overhauser effect

Abstract

Alkylation of 5‑acetyl-5-methyl-7-phenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine with ethyl bromide in heterogeneous system КОН–H2O–MeCN leads to the formation of the mixture of two isomers. The structures of the latter were elucidated by NOE experiment. Recrystallization of the obtained mixture from EtOAc results in the major product of alkylation, 5‑acetyl-4-ethyl-5-methyl-7-phenyl-4,7-dihydro[1,2,4]triazolo[1,5‑a]pyrimi­di­ne.

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Published
2013-12-20
Cited
How to Cite
Kolosov, M. A., Kulyk, O. G., Chepelieva, L. V., & Orlov, V. D. (2013). Ethylation of 5-acetyl-5-methyl-7-phenyl-4,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidine. Kharkiv University Bulletin. Chemical Series, (22), 39-44. https://doi.org/10.26565/2220-637X-2013-22-04

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