Analysis of DNA sequences CpG fine structure

Authors

Keywords:

DNA methylation, CpG sites, methylcytosine, isochor, hyston protein, CG island, intron, exon

Abstract

Numerical and graphical methods of CpG sites distribution in DNA sequences are introduced and described. Normalization of curve relative to the sequence length allows us to compare sequences by CpG accumulation characteristic and classify them by similarity of accumulation, but not only by their frequency. Using the introduced characteristics and similarity principle we show that there are differences in CpG sites accumulation inside DNA genes of organisms which differ by evolution and presence of DNA methylation. For species in which DNA methylation has no regulatory significance in imprinting processes and cell memory, the CpG sites distribution is random.

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Author Biographies

  • D. R. Duplij, Karazin Kharkov National University

    4, Svoboda Sq., Kharkov, 61077, Ukraine

  • Y. G. Shckorbatov, Karazin Kharkov National University

    4, Svoboda Sq., Kharkov, 61077, Ukraine

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Published

2003-06-05

Issue

Vol. 2 No. 13 (2003): Біофізичний вісник

Section

Molecular biophysics

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How to Cite

Analysis of DNA sequences CpG fine structure. (2003). Biophysical Bulletin, 2(13), 5-15. https://periodicals.karazin.ua/biophysvisnyk/article/view/12353

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