Fibril thermostability formed in vitro from collagen, synthesised in the skin under the effect of mechanical stretching
Keywords:
connective tissue, mechanical stretching, collagen, oxidative deamination, cross-linkage, thermostabilityAbstract
The effect of mechanical stretching of the skin of rats, on oxidative deamination of lysine and hydroxylysine ε-NH2-group, as well as functional properties of the synthesized type I collagen in them, were studied in vitro. It was shown that the content of free ε-NH2-groups in the skin collagen that is synthesized under the effect of mechanical stretching is higher, and the level of molecular cross-linkage is lower than in collagen that is synthesized without the effect. As a result, fibrils formed from the first collagen, are shorter and less thermostable than those synthesized without mechanical stretching.
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