Response of erythrocytes on changes of electrolyte content of the medium. Iv. Effect of organic anions
Keywords:
erythrocyte, shape, low ionic strength, sucrose, anion transport, organic anionsAbstract
The effect of organic anions acetate, oxalate citrate, tartrate, salicylate, Na2EDTA, and Na4EDTA on the dynamics of erythrocyte shape changes in sucrose media (morphological response, MR) was studied. It was established that among anions tested only oxalate and citrate demonstrated a similar mode of action relative to different phases of MR. The action of other anions was different from oxalate as well as from each other suggesting the specificity in their influence on cell shape under present conditions. In contract to monovalent inorganic anions which caused stabilization of discoid shape when added at phase 2 of MR, all organic anions rapidly converted the cells into the spheres. The data obtained allow us to exclude the positive transmembrane potential and ionic strength at least in the range up to 10 mm as a causal factor affecting dynamics of shape changes in nonelectrolyte media, however, do not exclude the possible involvement of conformation of membrane proteins. It is suggested that MR could be considered as a type of general cell reaction on changes in the ionic environment.
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