STABILITY OF DICATION OF DECAMETHOXINUM AS REVEALED BY SECONDARY ION MASS SPECTROMETRY

Authors

  • M. V. Kosevich B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine Author
  • V. A. Pashinskaya B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine Author
  • Z. Szilagyi Institute of Chemistry Hungarian Academy of Sciences Author
  • K. Vekey Institute of Chemistry Hungarian Academy of Sciences Author
  • V. S. Shelkovsky B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine Author
  • Yu. P. Blagoy B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine Author

Keywords:

decamethoxinum, secondary ion mass spectrometry, thermal degradation

Abstract

Stability of the dication of an antimicrobial drug decamethoxinum under the influence of various physical factors was studied. Significant differences in the pathways of transformation of decamethoxinum under the influence of heating and upon long-term storage were revealed By means of the secondary ion mass spectrometry it was shown that the changes in the medicine with time upon neglect of storage rules are connected, obviously, with the deleting of chlorine counterions from the crystalline sample with preservation of the structure of the dication, while upon thermal treatment a dequaternization of the quaternary nitrogens of decamethoxinum with formation of tertiary amines takes place.

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Author Biographies

  • M. V. Kosevich, B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine

     47 Lenin Ave., Kharkov 310164. Ukraine

  • V. A. Pashinskaya, B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine

    47 Lenin Ave., Kharkov 310164. Ukraine

  • Z. Szilagyi, Institute of Chemistry Hungarian Academy of Sciences

     Pustaszeri ut 59-67, H-1025 Budapest IL, Hungary

  • K. Vekey, Institute of Chemistry Hungarian Academy of Sciences

     Pustaszeri ut 59-67, H-1025 Budapest IL, Hungary

  • V. S. Shelkovsky, B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine

     47 Lenin Ave., Kharkov 310164. Ukraine

  • Yu. P. Blagoy, B.I. Verkin Institute fur Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine

     47 Lenin Ave., Kharkov 310164. Ukraine

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Issue

Vol. 2 No. 2 (1998): Біофізичний вісник

Section

Molecular biophysics

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How to Cite

STABILITY OF DICATION OF DECAMETHOXINUM AS REVEALED BY SECONDARY ION MASS SPECTROMETRY. (2015). Biophysical Bulletin, 2(2). https://periodicals.karazin.ua/biophysvisnyk/article/view/2444

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