Modeling the DNA structural transformations. Static deformations
Keywords:
DNA macromolecule, conformational transformations, static deformations, modeling, mesoscopic scalesAbstract
The mobility of the DNA macromolecule structural elements on the intermediate (mesoscopic) scales is considered. Using the two-component model of the conformational mobility of the double helix the static states (basic, metastable and static excitation), which may be observed experimentally are studied. The potential energy form of the system is determined for the conditions of the one conformation advantageous and for the conditions of the macromolecule with the equivalent and nonequivalent monomer stable states is found. The agreement of the theory with known experiment for deformed DNA fragment is demonstrated. The correlation between the macromolecule deformability and the number of the internal conformational excitations is marked.
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