H NMR investigation of the hetero-association of nogalamycin with aromatic anticancer antibiotics
Keywords:
hetero-association, nogalamycin, daunomycin, mitoxantrone, actinomycin D
Abstract
A complexation of antibiotic nogalamycin (NOG) with anticancer antibiotics, daunomycin, mitoxantrone and actinomycin D, was investigated in aqueous solution by means of 1H NMR spectroscopy (500 MHz). Equilibrium hetero-association parameters of the molecules studied were obtained and the most probable structures of 1:1 hetero-complexes in solution were calculated. It was shown that NOG forms complexes with aromatic antibiotics, characterized by intermediate energetic parameters as compared with the self-association parameters of these molecules. Conclusions regarding the distinctive features of 1:1 hetero-complexes of anticancer antibiotics in solution were made.
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Published
2005-06-05
Cited
How to Cite
Evstigneev, M., Rozvadovska, A., & Davies, D. (2005). H NMR investigation of the hetero-association of nogalamycin with aromatic anticancer antibiotics. Biophysical Bulletin, 1(15), 43-48. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/17987
Section
Molecular biophysics
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