The effects of mechanical stretching in skin on the thermostability of collagen synthesized in it

  • T. V. Zhukova Department of Biochemistry, V.N. Karazin Kharkov National University
  • Y. G Kot Department of Biochemistry, V.N. Karazin Kharkov National University
  • E. E. Persky Department of Biochemistry, V.N. Karazin Kharkov National University
Keywords: connective tissue, mechanical stretching, collagen, hydroxylation, glycolysation, thermostbility, denaturation

Abstract

The effects of mechanical stretching on denaturation parameters, as well as the degree of proline hydroxylation, glycolysation of lysine and hydroxylysine residues of I collagen in rat's skin have been studied in vitro. It was found that collagen synthesized in the skin under the influence of mechanical stretching, produces less thermostable fibrils than that synthesized without it. This effect appeared to be a result of decreased intensity of two enzymatic reactions of collagen primary structure processing - proline hydroxylation and glycolysation of lysine and hydroxylysine residues.

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Author Biographies

T. V. Zhukova, Department of Biochemistry, V.N. Karazin Kharkov National University

4 Svobody Sq., Kharkov 61077, Ukraine

Y. G Kot, Department of Biochemistry, V.N. Karazin Kharkov National University

4 Svobody Sq., Kharkov 61077, Ukraine

E. E. Persky, Department of Biochemistry, V.N. Karazin Kharkov National University

4 Svobody Sq., Kharkov 61077, Ukraine

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Published
2007-06-05
Cited
How to Cite
Zhukova, T. V., Kot, Y. G., & Persky, E. E. (2007). The effects of mechanical stretching in skin on the thermostability of collagen synthesized in it. Biophysical Bulletin, 1(18), 65-68. Retrieved from https://periodicals.karazin.ua/biophysvisnyk/article/view/12623
Section
Biophysics of complex systems