THE AGE PARTICULARITY OF ACTIVITIES NADP-DEPENDENT DEHYDROGENASE AND CYTOCHROME P-450 AND B5 CONTENTS IN RAT LIVER DURING OXIDATIVE STRESS INDUCED BY COBALT CHLORIDE

  • G. Ganusova
Keywords: oxidative stress, cobalt chloride, NADP-dependent dehydrogenase, cytochrome P-450, cytochrome b5, aging of the organism

Abstract

Activities of NADP-dependent dehydrogenase and microsomal cytochrome P-450 and b5 contents were studied in liver of rats of the different age after action of CoCl2. It was shown that cytochrome P-450 contents increased in 3 month old and remained on this level in old rats. The cytochrome b5 contents did not change with ageing. The activities of glucose-6-phosphate dehydrogenase and NADP-malate dehydrogenase decreased with ageing, but NADP-isocitrate dehydrogenase and 6-phosphogluconate dehydrogenase increased during ontogenesis. Cytochrome P-450 and b5 contents decreased after single injection CoCl2, more expressed after 7-fold CoCl2 in rats of all ages. Activities of glucose-6-phosphate dehydrogenase, NADP-isocitrate dehydrogenase and NADP-malate dehydrogenase increased after 7-fold injection CoCl2 of young and old rats.

Downloads

Download data is not yet available.
Published
2005-12-22
Cited
How to Cite
Ganusova, G. (2005). THE AGE PARTICULARITY OF ACTIVITIES NADP-DEPENDENT DEHYDROGENASE AND CYTOCHROME P-450 AND B5 CONTENTS IN RAT LIVER DURING OXIDATIVE STRESS INDUCED BY COBALT CHLORIDE. The Journal of V.N.Karazin Kharkiv National University. Series «Biology», 1(709), 33-38. Retrieved from https://periodicals.karazin.ua/biology/article/view/155
Issue
Vol. 1 No. 709 (2005)
Section
BIOCHEMISTRY

Authors retain copyright of their work and grant the journal the right of its first publication under the terms of the Creative Commons Attribution License 4.0 International (CC BY 4.0), that allows others to share the work with an acknowledgement of the work's authorship.