ROLE OF MICROCIRCULATORY ABNORMALITIES AND ANTI-INFLAMMATORY CYTOKINES IN PATHOGENESIS OF OSTEOARTHROSIS IN ADOLESCENTS

Abstract

There has been carried a study of connections between cytokine status (IL-1β, IL-6, PNP-α) and microcir­culation system (MCS) in adolescents at the age of 15–18, with knee joint osteoarthrosis (OA). MCS para­meters have been estimated by nail bed capillaroscopy; cytokine level has been measured by immunoassay method applying test system produced by «Proteinovyj Kontur», Saint-Petersburg, Russia. It has been estab­lished that inflammatory reaction in affected joints took place in ⅓ of patients and has been characterized by swelling, pain on palpation and movement, morning stiffness, local rise of temperature over knee joints. Anti-inflammatory cytokines level manifested a significant increase even without objective signs of synovitis. MCS parameters manifested some changes in perivascular background which has been characterized by blur­riness and paleness. Correlations between microcirculatory abnormalities and anti-inflammatory cytokine levels have been discovered. It has been established that an increase in cytokine level positively correlated with a decrease in blood circulation velocity and a decrease in quantity of capillaries in function.