HEART RATE VARIABILITY IN PATIENTS WITH HYPERTENSION, COMORBID WITH PEPTIC ULCER DISEASE, TAKING INTO ACCOUNT CIRCADIAN SYSTOLIC BLOOD PRESSURE

Abstract

In out-patient conditions patients with hypertension were investigated (n = 141): of which the core group consisted of 41 patients with hypertension (H) comorbid with peptic ulcer (PU); the comparison group 1 con­sisted of 58 patients with isolated H and comparison group 2 consisted of 42 patients with isolated РU. The frequency of circadian rhythm (CR) of systolic blood pressure (SBP) and heart rate variability (HRV) were studied, including taking into account the different types of CR SBP. Three types of CR SBP (dipper, non-dipper, knight-peacker) with a prevalence of pathological (45 % of non-dipper, 15 % of knight-peacker) CR SBP are characterized. Low Total Power (TP HRV) (1203 ms² ± 852) with the lowest values in the group with knight-peacker CR SBP (839 ± 462 ms²), and there is a significant removal of simpatovagalnogo balance (LF/HF) in the sympathic direction (3,3 ± 2,6) due to the non-dipper CR SBP (5,3 ± 2,6). Violation of or­thostatic reactions is observed from the side of TP HRV (increase on 44,8 %) in the dipper CR SBP, and the test with modulated breath (decrease on 47,2 %) from the side of the LF/HF in the non-dipper CR SBP.