THE TUMOR NECROSIS FACTOR-α AND C-REACTIVE PROTEIN EXPRESSION DYNAMICS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Автор(и)

  • J. C. Tantchou Tchoumi

Ключові слова:

myocardial infarction, proinflammatory cytokines, acutephasis proteins

Анотація

Myocardial infarction is one of the basical cause of population invalidisation and death that determinate the necessity  of  deepning pathogenetical researches in its development peculiarities  and the new  method elaboration of the manyfactorial disease effective treatment.  The aim of the investigation was to explore the proinflammatory cytokine: tumor necrosis factor-α (TNF-α) expression dynamics and C- reactive protein (CRP) in patients with acute myocardial infarction. 70 patients were involved in thе study and divided in 2 groups: in the 1 st group were 40 patients with Q- wave myocardial infarction were recruited, in the 2 nd group 30 patients with non Q – wave myocardial infarction. Serum levels of TNF-α  and CRP were measured on the first day  and twice  on the 7 th and the 28 th day  by ELISA. The results of the investigation showed that the inflammatory reaction caused mainly  by  TNF-α  and lesser than CRP was high on the 1 st day,  gradually decreased  to the 7 th , 28 th day  and  was more  significant in patients with Q- wave myocardial infarction. 

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Номер

Розділ

Clinical Research

Як цитувати

THE TUMOR NECROSIS FACTOR-α AND C-REACTIVE PROTEIN EXPRESSION DYNAMICS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION. (2015). Вісник Харківського національного університету імені В. Н. Каразіна. Серія «Медицина», 4, 115-120. https://periodicals.karazin.ua/medicine/article/view/7372