THE TUMOR NECROSIS FACTOR-α AND C-REACTIVE PROTEIN EXPRESSION DYNAMICS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
Abstract
Myocardial infarction is one of the basical cause of population invalidisation and death that determinate the necessity of deepning pathogenetical researches in its development peculiarities and the new method elaboration of the manyfactorial disease effective treatment. The aim of the investigation was to explore the proinflammatory cytokine: tumor necrosis factor-α (TNF-α) expression dynamics and C- reactive protein (CRP) in patients with acute myocardial infarction. 70 patients were involved in thе study and divided in 2 groups: in the 1 st group were 40 patients with Q- wave myocardial infarction were recruited, in the 2 nd group 30 patients with non Q – wave myocardial infarction. Serum levels of TNF-α and CRP were measured on the first day and twice on the 7 th and the 28 th day by ELISA. The results of the investigation showed that the inflammatory reaction caused mainly by TNF-α and lesser than CRP was high on the 1 st day, gradually decreased to the 7 th , 28 th day and was more significant in patients with Q- wave myocardial infarction.
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2. Лященко В. А., Дроженников В. А., Молотковская И. М. Механизмы активации иммунокомпе-тентных клеток. - М.: Медицина. 1988. 200 c.
3. Маянский А. Н., Маянский Д. Н. Очерки о нейтрофиле и макрофаге. - Новосибирск. 2 изд. 1989.
4. Маянский Д. Н., Маянская С. Д. // Тер. aрхив. 2001. №12. С. 84-88.
5. Нагорнев В. А. // Бюлл. м. экс. биологии и медицины. 1998. Т.106. №9. С. 277-280.
6. Назаров П.Г. СрБ+- лимфоциты и их роль в иммунорегуляции: Дисс…доктора мед. наук. Л. 1986.
7. Полявщиков А. В., Назаров П. Г. // Иммунология. 1993. №4. С. 6-10.
8. Полявщиков А. В. Иммуноцитотропные эффекты С-реактивного белка: Дисс…. канд. биол. наук. № Спб. 1992.
9. Токсанбаева С. Ж. Иммунорегуляторные свойства С-реактивного белка в эксперименте: Дисс… кан. мед. наук. М. 1989.
10. Aderka D., Engelmann H., Maor Y. et al. // J. Exp. Med. 1992. №175. P. 323-329.
11. Bazzoni F., Beutler B. // N. Engl. J. Med. 1996. №364. P. 1717-1725.
12. Blum A., Miller H. // Am. Heart J. 1998. №135. P. 161-166.
13. Blum A., Miller H. // Annual Rev. of Med. 2001. Vol. 52. P. 15-27.
14. Engelberts I., Moeller A., Schoen G. J. M. et al. // Lympho. Cyto. Res. 1991. №10. P. 69-75.
15. Gilmont R R, Dardano A., Engle J. S. et al. // J. Surg. Res. 1996. Vol. 1. №1. P. 175-182.
16. Gori AM, Brunelli T., Pepe G. // Eur. Heart J. 1998. Vol. 19. P. 506.
17. Kapadia SR. // Cardiol. Rev. 1997. Vol. 4. №7. P. 196-206.
18. Matsumori A., Yamada T., Suzuki H. // Brit. Heart J. 1994. Vol. 72. P. 561-566.
19. Nophar Y., Kemper O., Brakebusch C. et al. // Emblo J. 1990. №9. P. 3269-3278.
20. Pudil R., Pidrman V., Krejset J. et al. // Clin. Chim. Acta. 1999. №280 (1-2). P. 127-134.
21. Rauchhaus M., Dohner W., Koloczek V. et al. // J. am. Coll. Cardiol. 2000. №35 Suppl. P. 1183.
22. Samsonov M. Y., Tilz G. P., Pisklakov V. et al. // Clin. Immunol. Immunopatho. 1995. №74. P. 31-34.
23. Scannell G., Waxman K., Vazini N. et al. // J. Surg. Res. 1995. №59. P. 141-145.
24. Sharma R., Anker SD. // Congest. Heart Fail. 2002. Vol. 1. №8. P. 23-28.
25. Tendera M, Wysoki H. // Eur. Heart J. 1999. Vol. 20. P. 1445-1446.
26. Thorne S. A., Abbot S. E., Stevens C. R. // Atheerosclerosis.1996. Vol. 127. P. 167-176.
27. Vaddi K., Nicolini F. A., Mehta P. // Circulation. 1994. Vol. 90. P. 694-699.
28. Weckmann A. L., Acocer.Varela J. K. // Semin. Arthr. Rheum. 1996. Vol. 26. P. 539-557.
29. Wiedermann CJ, Beimpold H, Herold M et al. // J. Am. Coll. Cardiol.. 1993. Vol. 7. №22. P. 1897-1901.
30. Zasmeta G., Homykewyez S., Stepen E. et al. // Eur. Heart J. 1997. 18 Suppl. Abstr 236.
31. Zhang M., Tracey K. J. // The Thompson ed.- Academic press. New York. 1998. P. 515-548.
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