CHANGE OF LEVELS TNF-α AND sTNFR FOR THE PATIENTS WITH A CHRONIC HEART FAILURE ON A BACKGROUND OF THERAPY

  • Lie In
Keywords: the factor of a necrosis of a tumor alpha, receptors of the factor of a necrosis of a tumor, chronic heart failure

Abstract

The changes of a level TNF-ά  and sTNFR in serum of blood for the patients with a chronic heart failure (СН) on a background of therapy are researched. 64 patients with СН II-IV FC are inspected according to NYHA by functional classification. The patients with СН III-IV FC are divided into 2 groups: with a cardiac cachexia (CC) and without СC. Control group - 16 practically healthy people. Before treatment a level of sTNFR1 and sTNFR2 in serum of blood is defined by ELISA method. The observed data allow to utilize the obtained data as a criterion at production of the diagnosis СН and evaluation of efficacy of the treatment. The degree of augmentation of concentration of the investigated factors in serum of blood allows to estimate a degree of manifestation СН, that would entitle the usage of antagonists in the therapy.

Downloads

Download data is not yet available.

References

1. Suffredini A.F., Fromm R.E., et.al. // N Engl J Med. 1989. Vol. 321. P. 280-287.

2. Hegewisch S, Weh H.J., et.al. // Lancet. 1990. Vol. 2. P. 294-295.

3. Millar A.B., Singer M., et.al. // Lancet. 1989. Vol. 2. P. 712-713.

4 . Yokoyama T. et.al. // J Clin Invest. 1993. Vol. 92. P. 2303-2312.

5. Чжан Гуанчжэн и др. // Китайская кардиология. 1998. Т. 3ю № 3. С. 185-187.

6. Mc Murray J., Abdullah I., Dargie H.J., et.al. // Br Heart J. 1991 Nov. Vol. 66. № 5. P. 356-358.

7. Torre Amione G. et.al. // Circulation. 1996 Feb 15. Vol. 93. № 4. P. 704-711.

8. Levine B. et.al. // N Engl J Med. 1990. Vol. 323. P. 236-241.

9. Ferrari R., Bachetti T., et.al. // Circulation. 1995. Vol. 92. P. 1479-1486.

10. Чжу Сюнь. Техника определения клеточного фактора, Издательство “Сhang chun”. 1994. 592 c.

11. Ян Синьго, Ши Сянюнь, Современная диагностика и терапия сердечной недостаточности. Первое из-дание, Народное военно-медицинское издательство. 1997. С. 65-77.
How to Cite
In, L. (1). CHANGE OF LEVELS TNF-α AND sTNFR FOR THE PATIENTS WITH A CHRONIC HEART FAILURE ON A BACKGROUND OF THERAPY. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (3), 95-97. Retrieved from https://periodicals.karazin.ua/medicine/article/view/7385
Issue
No. 3 (2002)
Section
Clinical research

The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.