CLINICO-PHYSIOLOGIC SIGNIFICANCE OF HEART RATE VARIABILITY IN CHRONIC ISCHEMIC HEART DISEASE
Keywords:
of heart rate variability, ischemic heart disease, cardiac death, prognoses, informative parameters
Abstract
The paper represents of the results of analysis of heart rate variability (HRV) in patients with chronic ischemic heart disease (IHD) in the context of search for informative characteristics for prognoses of IHD development and its end-points based on data of 297 healthy subjects and 4561 IHD patients (pts) (range of age was 20-84yr’s). HRV was analyzed by means of calculation of HR power spectrum, HR responses to complex of tests (active orthostatic test, bicycle ergometry, night sleep), non-linear dynamics analysis methodology and baroreflex sensitivity. There was shown, that the pattern of HRV depend on level of development of IHD and its complications or leading pathology, having an impact to HR parameters due changes of mechanism and particular point of influence to HR autonomic control. The level of impact depends of the changes in cardiovascular functional state, particularly of development of congestive heart failure. HRV changes were dependent on increase of an impact of humoral-metabolic HR control due to depression of nervous reflex control, particularly parasympathetic one. Because of that, changes of HRV in IHD pts enable to follow the tendencies of development and treatment efficacy. As it was shown for myocardial infarction, in chronic IHD pts, there were possibility to use HRV characteristics, reflecting parasympathetic control, for cardiac death prognoses.
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References
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66. Pfeffer M.A., Braunwald E., Moye L.A., et.al. // N. Engl. J. Med. 1992. Vol. 327.P. 669.
67. Жемайтите Д. Вегетативная регуляция синусового ритма сердца у здоровых и больных // Анализ сер-дечного ритма / Под ред. Д.Жемайтите, Л. Тельксниса. Вильнюс. 1982. P. 22-32.
2. Oliveira M., Staunton A., Camm A.J., Malik M. // Pacing Clin. Electrophysiol. 1998. Vol. 21. P. 603.
3. Bigger J.T., Fleiss J., Steinman R.C., et.al. // Circulation. 1991. Vol. 85. P. 164.
4. Eckberg D.L., Drabinsky M., Braunwald E. // N. Engl. J. Med. 1971. Vol. 285. P. 877.
5. Farrell T.G., Bashir Y., Cripps T., et.al. // J. Am. Coll. Cardiol. 1991. Vol. 18. P. 687.
6. Kleiger R.E., Miller J.P., Bigger J.T., et.al. // Am. J. Cardiol. 1987. Vol. 59. P. 256.
7. Lombardi F., Sandrone G., Pernpruner S., et.al. // Am. J. Cardiol. 1987. Vol. 60. P. 1239.
8. Žemaitytė D., Brožaitienė J. // Third USA - USSR joint symposium.- Sudden Cardiac Death. 1984.
9. Ewing D.J. // Clin. Cardiol. 1991. Vol. 14. P. 683.
10. Billman G.E., Schwartz P.J., Stone H.L. // Circulation. 1982. Vol. 66. P. 874.
11. Eckberg D.L., Sleight P. // In Human Baroreflexes in Health and Disease. Oxford. 1992. P. 303.
12. Schwartz P.J., Vanoli E., Stramba - Badiale M. et.al. // Circulation. 1988. Vol. 78. P. 969.
13. La Rovere M.T., Specchia G., Mortara A. et.al. // Circulation. 1988. Vol. 78. P. 816.
14. Bigger J.T. Jr., La Rovere M.T., Steinman R.C., et.al. // J. Am. Coll. Cardiol. 1989.Vol. 14. P. 1511.
15. Odemuyiwa O., Malik M., Farrell T., et.al. // PACE. 1991. Vol. 14. P. 1986.
16. Bosner M.S., Kleiger R.E. // Heart Rate Variability / Ed. M. Malik, A.J. Camm.- Armonk, N.Y., Futura Pub-lishing Company Inc., 1995. P. 331.
17. De Ferrari G.M., Vanoli E., Schwartz P.J. // Vagal Control of the Heart: Experimental Basis and Clinical Im-plications / Ed. M.N. Levy, P.J. Schwartz.- Armonk, N.Y., 1994. P. 612.
18. Lown B., Verrier R.L. // N. Engl. J. Med. 1976. Vol. 294. P. 1165.
19. Schwartz P.J., Billman G.E., Stone H.L. // Circulation.- 1984. Vol. 69. P. 780.
20. Warner M.R., Zipes D.P. // Vagal Control of the Heart: Experimental Basis and Clinical Implications / Ed. M.N. Levy, P.J. Schwartz.- Armonk, N.Y., 1994. P. 261.
21. Waxman M.B., Cameron D., Wald R.W. // Vagal Control of the Heart: Experimental Basis and Clinical Impli-cations / Ed. M.N. Levy, P.J. Schwartz.- Armonk, N.Y., 1994. P. 579.
22. Webb S.W., Adgey A.A., Pantridge J.F. // Br. Med. 1972. Vol. 3. P. 89.
23. Zipes D.P., Miyazaki T. // Cardiac Electrophysiology: From Cell to Bedside / Ed. D.P. Zipes, J. Jalife.- Phila-delphia, 1990. P. 312.
24. Zipes D.P., Lewy M.N., Cobb L.A. et.al. // Circulation. 1987. Vol. 76. P. 1.
25. Barber M.J., Mueller T.M., Henry D.P. et.al. // Circulation. 1983. Vol. 67. P. 787.
26. Жемайтите Д. Статический анализ деятельности сино-аурикулярного узла в норме и патологии // Математические методы анализа сердечного ритма. M. 1968. C. 80.
27. Zipes D.P. // Circulation. 1990. Vol. 82. P. 1093.
28. Trimarco B., Cherchia S., Lembo G. et.al. // Circulation. 1990. Vol. 81. P. 1792.
29. De Ferrari G.M., Vanoli E., Stramba-Badiale M. et.al. // Am. J. Physiol. 1991. Vol. 261. P. H63.
30. Farrell T.G., Paul V., Cripps T.R., et.al. // Circulation. 1991. Vol. 83. P. 945.
31. Chen J.S., Wang W., Bartholet T., et.al. // Circulation. 1991. Vol. 83. P. 260.
32. Ellenbogen K.A., Mohanty P.K., Szentpetery S., et.al. // Circulation. 1989. Vol. 79. P. 51.
33. Stefenelli Th., Bergler-Klein J., Globits S. et.al. // Eur. Heart. J. 1992. Vol. 13. P. 902.
34. Takase B., Kurita A., Noritake M. et.al. // J. of Electrocardiol. 1992. Vol 25. P. 79.
35. White C.W. // Am. J. Physiol. 1981. Vol. 240. P. H793.
36. White C.W. // Am. J. Physiol. 1981. Vol. 241. P. H778.
37. Casolo G.C., Stroder P., Sulla A. et.al. // J. Heart Failure. 1993. Vol. 1. P. 507, Abstract.
38. Dibner-Dunlap M.E., Thames M.D. // Circulaition Research. 1989. Vol. 65. P. 1526.
39. Bristow J.D., Honour A.J., Pickering G.W., et.al. // Circulation. 1969. Vol. 39. P. 48.
40. Guzzetti S., Piccaluga E., Casati R. et.al. // J. Hypertense. 1988. Vol. 6. P. 711.
41. Mancia G., Parati G., Pomidossi G., et.al. // Hypertension. 1986. Vol. 8. P. 147.
42. Watkins P.J., Mackay J.D. // Ann. Intern. Med. 1980. Vol. 92(Part 2). P. 304.
43. Takase B., Kurita A., Noritake M. et.al. // J. of Electrocardiol. 1992. Vol. 25. P. 79.
44. Wieling W., Borst C., Van Brederode J. F. // Clin. Sci. 1983. Vol. 64. P. 581.
45. Eckberg D.L., Harkins S.W., Fritsch J.M. et.al. Baroreflex control of plasma norepinephrine and heart period in healthy subjects and diabetic patients // J. Clin. Invest. 1986. Vol. 78. P. 366.
46. Vanoli E., De Ferrari G.M., Stramba-Badiale M. et.al. // Circulation Research. 1991. Vol. 68. P. 1471.
47. Miyazaki T., Zipes D.P. // Circulation Research. 1989. Vol. 64. P. 437.
48. Vatner S.F., Higgins C.B., Braunwald E. // Cardiovasc. Res. 1974. Vol. 8. P. 153.
49. Dambrink J.H., Tuininga Y.S., van Gilst W.H. et.al. // CATS Investigators. Captopril and Thrombolysis Study. Br. Heart J. 1994. Vol. 72. P. 514.
50. Kontopoulos A.G., Athyros V.G., Papageorgiou A.A. et.al. // Coron. Artery Dis. 1997. Vol. 8. P. 517.
51. Zhang Y.H., Song Y.C., Zhu J. et.al. // Am. J. Cardiol. 1995. Vol. 76. P. 1045.
52. Žemaitytė D., Varoneckas G., Ožeraitis E., Zakarevičius L., Valvonienė V. // Proceedings of the IX Interna-tional Conference on Electrical Bio-Impedance In conjunction with the European Community Concerted Ac-tion on Impedance Tomography / Eds E. Gersing, M. Schaefer. Heidelberg, Germany, September 29-30. 1995. P. 192.
53. Žemaitytė D., Varoneckas G., Plauška K. et.al. // Int. J. Psychophisiology. 1986. Vol. 4 P. 129.
54. Žemaitytė D., Varoneckas G., Dilkaitė V., Žiliukas G. // Lithuanian Journal of Cardiology.1998 (В печати).
55. Dilkaitė V., Varoneckas G., Martinkėnas A., Žemaitytė D.//Lithuanian Journal of Cardiology. 1997. Vol. 4. № 1.
56. Žemaitytė D. // Физиология Человека. 1989. №l. 15.- С. 30-47.
57. Žemaitytė D., Varoneckas G., Žiliukas G. // Lithuanian Journal of Cardiology. 1998 (В печати).
58. Žemaitytė D., Varoneckas G., Žiliukas G. // Lithuanian Journal of Cardiology. 1998 (В печати).
59. Randall W.C., Ardell J.L. // Cardiac Electrophysiology: From Cell to Bedside / Ed. D.P.Zipes, J.Jalife. Phila-delphia, 1990. P. 291.
60. Warner M.R., Zipes D.P. // Vagal Control of the Heart: Experimental Basis and Clinical Implications / Ed. M.N. Levy, P.J. Schwartz. Armonk, N.Y., 1994. P. 261.
61. Alessi R., Nusynowitz M., Abildskov J.A. et.al. // Am. J. Physiol. 1958. Vol. 194. P. 406.
62. Corr P.B., Yamada K.A., Witkowski F.X. // The Heart and Cardiovascular System. Vol. II / Ed. H.A.Fozzard, E.Haber, R.B.Jennings et.al. New York, N.Y., Raven Press, 1986. P. 1343.
63. Žemaitytė D., Valytė G. // Lithuanian Journal of Cardiology. 1997. Vol. 4. № 2. P. 11.
64. Žemaitytė D., Žiliukas G., Varoneckas G., et.al. // Medicina. 1998. Vol. 34. №. 11. P. 1079.
65. Sigurdson A., Sweberg K. // Eur. Heart. J. 1994. Vol. 127. P. 14.
66. Pfeffer M.A., Braunwald E., Moye L.A., et.al. // N. Engl. J. Med. 1992. Vol. 327.P. 669.
67. Жемайтите Д. Вегетативная регуляция синусового ритма сердца у здоровых и больных // Анализ сер-дечного ритма / Под ред. Д.Жемайтите, Л. Тельксниса. Вильнюс. 1982. P. 22-32.
How to Cite
Zemaityte, D. (1). CLINICO-PHYSIOLOGIC SIGNIFICANCE OF HEART RATE VARIABILITY IN CHRONIC ISCHEMIC HEART DISEASE. The Journal of V. N. Karazin Kharkiv National University, Series "Medicine", (3), 59-80. Retrieved from https://periodicals.karazin.ua/medicine/article/view/7381
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