GLUCOSAMINOGLYCANS ROLE IN PHYSIOLOGICAL GESTATION
Abstract
Pregnancy is actually associated with adaptive changes of structure and function of connective tissue those are due to the fetoplacental system development. It was investigated N-acetylglucosamine and chondroitinsulfates blood serum level in 128 healthy pregnant women and in 34 patients with fetoplacental insufficiency. It was determined an associated with the progress of pregnancy increased level of N-acetylglucosamine and constant concentration of sulfated glycosaminoglycans. Fetoplacental insufficiency was characterized with low N-acetylglucosamine and sulfated glycosaminoglycans amount. The lack of these substances could be connected with oxidative stress which is due to the systemic inflammatory response. The drugs which could promote to the glucosamine and chondroitinsulfates synthesis and their exogenous donation are thought to be effective in fetoplacental insufficiency prevention.
Downloads
References
2. Грищенко О.В., Лахно И.В. // Проблеми медичної науки та освіти. - 2004. - № 3. - С. 88-90.
3. Зупанець І.А., Туляков В.О. // Медична хімія. - 2003. - Т. 5. - № 4. - С. 31-34.
4. Зупанець І.А., Туляков В.О., Осадченко С.М. // Клінічна фармація. - 2001. - Т. 5. - № 1. - С. 14-17.
5. Лапса Ю.Ю., Слуцкий Л.И. //Тр. ІІІ Всесоюз. съезда ортоп.-травм. - М. - 1975. - Ч. 1. - С. 158-159.
6. Gude N.M., King R,G., Brennecke S.P. // Semin. Perinatol. - 2001. - № 3. - P. 196-201.
7. Norberg S., Powell T.L., Jansson T. // Pediatr. Res. - 1998. - Vol. 44. - № 2. - P. 233-238.
8. Redman C.W., Sargent I.L. // Gynecol. Obstet. Fertil. - 2001. - Vol. 29. - № 7-8. - P. 518-522.
9. Sgambati E., Biagiotti R., Marini M., et. al. // Placenta. - 2002. - Vol. 23. - № 6. - P. 503-515.
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.