EXPERIMENTAL INVESTIGATION OF D-GLUCOSAMINE INFLUENCE ON INTRAUTERINE DEVELOPMENT OF FETAL RATS
Abstract
It was performed an assessment of possible teratogenic and embryotoxic effects on female rats. It was calculated the quantity of luteal glands in rats ovaries, quantity of alive and newborn rats, also was evaluated the lethal effects before and after implantation, macroscopic assessment to determine visible malformation, investigation of internal organs and bony skeleton. The obtained data demonstrates the absence of embryolethal effect of D-glucosamine dose 90mg/kg. We had proved the absence of visible malformations in 20 days fetuses included skeleton malformations. So it was concluded that D-glucosamine had no teratogenic effects. These results was the only first step to D-glucosamine application in perinatology.
Downloads
References
2. Доклінічні дослідження лікарських засобів (методичні рекомендації) /За редакцією О.В. Стефано-ва. -К.: “Авіцена”. - 2001. - С. 82-83; 115-138.
3. Зайченко А.В., Шевченко О.И., Викторов А.П., Сторчак А.В. Основы рационального применения лекарств и фармацевтической опеки в акушерско-гинекологической практике: Монография /Под ред. И.А. Зупанца, О.В. Грищенко. -Харьков:Золотые страницы. - 2003. - 304 с.
4. Мет. реком. по експеримент. вивченню ембріотоксичної дії лікарських засобів. -Київ.- 2000. - 42 с.
5. Руденко В.Г. // Medicus Amicus. - 2003. - № 6. - С. 5.
6. Стентон Г. Медико-биологическая статистика -М.:Практика. - 1999. - 459 с.
7. Чайка В.К. Основи репродуктивной медицины. - Донецк:ООО «Альматео». - 2001. - 608 с.
8. Яблучанский Н.И. // Medicus Amicus. - 2003. - № 2. - С. 12.
The Journal of V. N. Karazin Kharkiv National University, series Medicine has following copyright terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work, with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.