HEART RATE AND ARTERIAL PRESSURE VARIABILITY INDICES IN PATIENTS WITH ARTERIAL HYPERTENSION IN GROUPS OF TREATMENT WITH BETA ADRENERGIC ANTAGONIST, INHIBITOR OF ANGIOTENSINCONVERTING ENZYME AND THEIR COMBINATIONS AND CLASSES OF ECG QRS COMPLEX DURATION

Abstract

Studied indicators of heart rate and arterial pressure variability (HRV, AP) in patients with arterial hypertension (AH) in treatment groups of beta -blocker (BB), inhibitors of angiotensinconverting enzyme (IACE) and their combination classes and duration of the QRS complex ECG ≤ 100 and > 100 ms.
138 patients with AH of the 1-2 degrees (60 men and 78 women) at the age of 57 ± 17 years old were examined. Registration and measurement of QRS complex duration and indices of HRV ECG were done on computer electrocardiograph conducted «Cardiolab+». In groups of thera-py classes of ECG QRS complex duration <100 ms and ≥100 ms were derived. Patients were treated with lisinopril in the average daily dose of 20 mg, bisoprolol - 5 mg. Patients were assessed before, after 2 weeks, 1, 6 and 12 months after of therapy. HRV was evaluated TP, VLF, LF, HF, SAP, DAP in groups of IACE, BB and IACE + BB and classes QRS ECG. The data were processed with the help of Microsoft Excel program. In patients with AH in IACE group the best response of HRV indices ontherapy was indicated in the class of ECG QRS complex duration ≤
100 ms and in group IACE+ B B− > 100 ms. In patients with AH of ECG QRS complex duration ≤ 100 ms in antihypertensive therapy IACE lizinopril is preferable with ECG QRS complex duration > 100 ms – combination of IACE lizinopril and BB bisoprolol.