Kinetic model of changes in genetic control of cells in state of proliferation and differentiation
Keywords:
proliferation, differentiation, reaction rate constant, kinetic model, genetic controlAbstract
In this work it is built kinetic model of changes in genetic control of cells in state of proliferation and
differentiation. It is shown that proliferation and differentiation in cells are controlled on gene,chromosomal, membrane and cellular levels. Onset of proliferation is determined by histone genes,transport genes and genes-stimulators of proliferation. Activation of these genes is mediated bytranscriptional factors which are produced by cell after activation of cell cycle genes, which isconditioned by the level of depolarization of cell membrane. Onset of differentiation is determined byactivation of structural genes and synthesis of structural cell proteins. Activation of these genes is conditioned by hyperpolarization of cell membrane. Our kinetic model assumes and integrates changes onall levels in cells in state of proliferation and differentiation.
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