Modeling protein adsorption onto lipid monolayer surface
Keywords:
lipid monolayer, protein sorption, Frumkin isothermAbstract
Using the modified Frumkin approach, the adsorption of protein onto the surface of lipid monolayer has
been simulated allowing for the different types of protein-lipid interactions. The results were presented in
terms of the monolayer surface pressure increase induced by protein sorption ( ) as a function of initial
surface pressure ( 0). The simulated curves were obtained under varying a range of interaction
parameters. It was suggested that the trend of 0 ( ) plot allows to distinquish between protein
interfacial localization and its penetration into lipid monolayer. The theoretical predictions are in accord
with the experimental observations available in literature
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