H NMR investigation of the hetero-association of nogalamycin with aromatic anticancer antibiotics

Authors

  • M.P. Evstigneev Department of Physics, Sevastopol National Technical University Author
  • A.O. Rozvadovska Department of Physics, Sevastopol National Technical University
  • D.B. Davies School of Biological and Chemical Sciences, Birkbeck college, University of London Author

Keywords:

hetero-association, nogalamycin, daunomycin, mitoxantrone, actinomycin D

Abstract

A complexation of antibiotic nogalamycin (NOG) with anticancer antibiotics, daunomycin, mitoxantrone and actinomycin D, was investigated in aqueous solution by means of 1H NMR spectroscopy (500 MHz). Equilibrium hetero-association parameters of the molecules studied were obtained and the most probable structures of 1:1 hetero-complexes in solution were calculated. It was shown that NOG forms complexes with aromatic antibiotics, characterized by intermediate energetic parameters as compared with the self-association parameters of these molecules. Conclusions regarding the distinctive features of 1:1 hetero-complexes of anticancer antibiotics in solution were made.

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Author Biographies

  • M.P. Evstigneev, Department of Physics, Sevastopol National Technical University

    Sevastopol, 99053, Ukraine

  • A.O. Rozvadovska, Department of Physics, Sevastopol National Technical University

    Sevastopol, 99053, Ukraine

  • D.B. Davies, School of Biological and Chemical Sciences, Birkbeck college, University of London

    UK

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Published

2005-06-05

Issue

Vol. 1 No. 15 (2005): Біофізичний вісник

Section

Molecular biophysics

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How to Cite

H NMR investigation of the hetero-association of nogalamycin with aromatic anticancer antibiotics. (2005). Biophysical Bulletin, 1(15), 43-48. https://periodicals.karazin.ua/biophysvisnyk/article/view/17987