N-butanol and N-hexanol effects on anion transport in red blood cells
Keywords:
red cell, n-butanol, n-hexanol, anion transport, Jacobs-Stewart cycleAbstract
N-butanol and n-hexanol effects on anion transport in human, cheep, and chicken red cells were investigated in the work. Anion transport was measured indirectly by recording changes in extracellular medium pH. Change in pH is known to occur as a result of Cl-/HSO4- exchange by means of anion exchanger: band 3 protein. The constant of the rate of hydrogen ions entering K2 has been calculated in the work. Both n-butanol and n-hexanol reduce the constant of the rate of hydrogen ion entering in red cells of all studied species, which testifies to slowing down the HSO4- transport into a cell in n-alkanol presence. Thus, both n-butanol and n-hexanol may be assumed to interact with band 3 protein in red cells by changing their functional state.
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