The effects of mechanical stretching in skin on the thermostability of collagen synthesized in it

Authors

  • T. V. Zhukova Department of Biochemistry, V.N. Karazin Kharkov National University Author
  • Y. G Kot Department of Biochemistry, V.N. Karazin Kharkov National University Author
  • E. E. Persky Department of Biochemistry, V.N. Karazin Kharkov National University Author

Keywords:

connective tissue, mechanical stretching, collagen, hydroxylation, glycolysation, thermostbility, denaturation

Abstract

The effects of mechanical stretching on denaturation parameters, as well as the degree of proline hydroxylation, glycolysation of lysine and hydroxylysine residues of I collagen in rat's skin have been studied in vitro. It was found that collagen synthesized in the skin under the influence of mechanical stretching, produces less thermostable fibrils than that synthesized without it. This effect appeared to be a result of decreased intensity of two enzymatic reactions of collagen primary structure processing - proline hydroxylation and glycolysation of lysine and hydroxylysine residues.

Downloads

Download data is not yet available.

Author Biographies

  • T. V. Zhukova, Department of Biochemistry, V.N. Karazin Kharkov National University

    4 Svobody Sq., Kharkov 61077, Ukraine

  • Y. G Kot, Department of Biochemistry, V.N. Karazin Kharkov National University

    4 Svobody Sq., Kharkov 61077, Ukraine

  • E. E. Persky, Department of Biochemistry, V.N. Karazin Kharkov National University

    4 Svobody Sq., Kharkov 61077, Ukraine

Downloads

Published

2007-06-05

Issue

Vol. 1 No. 18 (2007): Біофізичний вісник

Section

Biophysics of complex systems

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

How to Cite

The effects of mechanical stretching in skin on the thermostability of collagen synthesized in it. (2007). Biophysical Bulletin, 1(18), 65-68. https://periodicals.karazin.ua/biophysvisnyk/article/view/12623

Most read articles by the same author(s)