OPIATERGIC MECHANISMS OF SPONTANEOUS AND INDUCED LOCOMOTOR ACTIVITY DETERIORATIONS IN RATS UNDER THE INFLUENCE OF TRANSCRANIAL MAGNETIC STIMULATION
Keywords:
transcranial magnetic stimulation, open field, posture-tonic reactions, naloxon, opiatergic mechanisms of the brainAbstract
In acute experiments on Wistar rats it was shown that transcranial magnetic stimulation (TMS) (1,5 Тl, 20 impulses, 30 min from the moment of cessation of TMS) is followed by the decreasing of those indices which were determined in «open field» test. Namely, the number of crossed squares as well as the number of rearings were substantially reduced. Naloxon (1,0 and 10,0 mg/kg, i.p.) induced dosage-depended protective action with regard to TMS-induced effects upon animal's behaviour. The enlargement of opiate-induced components of posture-tonic reactions- explozivness, exophtalm, adduction of extremities, decreasing of pain-induced reactions, increasing of tail tonus, loosing of the ability to hold on the rode and grasping of the pencil were seen. Mentioned behavioral reactions were blocked by naloxon (10,0 mg/kg, i.p.). The conclusion was made on the activation fo kapa-opiate receptors in the course of TMS.
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