THE FINDINGS OF PROTEIN PEROXIDATION AND ANTIOXIDATIVE DEFENSE IN CHILDREN WITH DIFFERENT MYOCARDIAL PATHOLOGIES

Анотація

Objective: To establish the character of changes in protein peroxidation (PP) and antioxidative defense (AD) in children with myocardial pathologies (MP) at early stages of chronic cardiac insufficiency formation. There were examined 283 children, aged 10-18 (mean age 14,86±0,15 yr), with MP: myocardiofibrosis (n=54),  dysplastic cardiomyopathy (n=56),  dilatational cardiomyopathy (n=6), hypertrophic cardiomyopathy (n=12), rhythm disorders (n=141), and myocardium overstrain syndrome (n=14). 67 practically healthy chil-dren of the same age served as a control group. There were studied cardiac morphofunctional characteristics (ECG, echoCG), carbonylated proteins content, as well as superoxiddysmutase (SOD) and glutathione peroxidase (GP) activity. It was established that in all variants of myocardial pathology in children there was observed an activation of PP process, more pronounced in cases of primary cardiomyopathy. The process was accompanied by differently directed changes in the system of AD: an increase in GP activity in cases of  hypertrophic cardiomyopathy, a tendency to a certain decrease in SOD activity in cases of primary cardio-myopathy, and a decrease in GP activity in the myocardium overstrain syndrome. At the initial signs of cardiac insufficiency an activation of antioxidative system was observed that could be an indirect evidence of intensification of free radical processes.