CLINICAL ASPECTS OF THE LIVER MICROSOMAL CYTOCHROME P-450 SYSTEM FUNCTIONING

Автор(и)

  • V.I. Padalko
  • T.V. Sevastyanova

Ключові слова:

сytochrome P-450, multiple forms, drug-drug interactions

Анотація

In the present review modern representations about cytochrome P-450 system  and  roles of its major multiple forms in an organism are generalized. Drugs induction or inhibition of this system are discussed. Important for clinic  interactions of drugs with P-450 enzymes  are given and practical ways of prevention or minimization of negative consequences of interactions of medical products are discussed. 

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