THE ROLE OF LOCAL AND CIRCULATING UNITS OF THE SIMPATHO-ADRENAL SYSTEM IN FORMING CEREBROISCHEMIC ARTERIAL HYPERTENSION

Abstract

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180 people were examined, among them there were 30 healthy persons and 150 persons who were ill with arterial hypertension at the age of 39-63. We found out that 58 of them had essential hypertension , 44 – arterial hypertension with endothelial dysfunction and 48 – cerebroischemic arterial hypertension. The brain blood flow was determined by B-mode and pulse color Doppler. The plasma catecholamin levels were determined by RIA. The evaluation of erythrocyte catecholamin level in red blood cells was performed with the help of a digital image analysis system . The analysis of the obtained results showed that the endothelial dysfunction of extracranial arteries and their structural remodelling of hypertensive patients depended more on the activity of tissue component of simpatho-adrenal system than on catecholamin level in blood plasma. Cerebroischemic arterial hypertension forming is accompanied by damaging mechanisms of interrelation between the plasma catecholamin activity and processes of their transmembrane transportation and intracellular deposition. At the same time the decrease of plasma catecholamins influence on mechanical properties of endothelium is associated with the decrease of endothelium-dependent vasodilation contribution to ensuring adequate cerebral perfusion even under significant hyper sumpathicotonia.